CD8-alpha Antibody (0.N.66): sc-70791
- CD8-α Antibody (0.N.66) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against the C-terminus of CD8-α of human origin
- recommended for detection of CD8-α of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See CD8-α (D-9): sc-7970 for CD8-α antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD8-α Antibody (0.N.66) for WB and IHC(P) applications. These reagents are now offered in bundles with CD8-α Antibody (0.N.66) (see ordering information below).
CD8-α Antibody (0.N.66) is a mouse monoclonal IgG1 kappa light chain antibody raised against the C-terminus of human CD8-α, suitable for detecting CD8-α of human, mouse, and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). CD8-α, also known as CD8A, Leu-2, or T8 antigen, is a transmembrane glycoprotein predominantly expressed on the plasma membrane of cytotoxic T lymphocytes (CD8+ T cells) and some natural killer cells. CD8-α localization on the cell surface is crucial for functioning as a co-receptor with the T cell receptor (TCR), where CD8-α binds to MHC class I molecules presented by antigen-presenting cells (APCs), enhancing antigen recognition and signal transduction. This interaction is essential for the activation, development, and cytotoxic function of CD8+ T cells, playing a significant role in immune surveillance against intracellular pathogens and tumor cells. Anti-CD8-α antibody (0.N.66) aids in the study of T cell-mediated immunity, identification of CD8+ T cell populations, and provides valuable insights into immune responses in various pathological conditions.
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CD8-alpha Antibody (0.N.66) References:
- Gamma delta T cells as mediators of mucosal tolerance: the autoimmune diabetes model. | Hänninen, A. and Harrison, LC. 2000. Immunol Rev. 173: 109-19. PMID: 10719672
- Intestinal CD8 alpha alpha and CD8 alpha beta intraepithelial lymphocytes are thymus derived and exhibit subtle differences in TCR beta repertoires. | Imhof, BA., et al. 2000. J Immunol. 165: 6716-22. PMID: 11120789
- Dendritic cell development from common myeloid progenitors. | Manz, MG., et al. 2001. Ann N Y Acad Sci. 938: 167-73; discussion 173-4. PMID: 11458504
- Beta-chain broadens range of CD8 recognition for MHC class I molecule. | Karaki, S., et al. 1992. J Immunol. 149: 1613-8. PMID: 1506684
- Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets. | Crozat, K., et al. 2010. Immunol Rev. 234: 177-98. PMID: 20193019
- A second chain of human CD8 is expressed on peripheral blood lymphocytes. | Shiue, L., et al. 1988. J Exp Med. 168: 1993-2005. PMID: 3264320
- Regions of the CD8 molecule involved in the regulation of CD2-mediated activation. | Franco, MD., et al. 1994. Cell Immunol. 157: 341-52. PMID: 7520836
- Production of IL4 by non-Th2 T-cell subsets: possible role of CD4-CD8- alpha beta TCR+ and CD4 subset T cells in T helper subset regulation. | Zlotnik, A. and Bean, AG. 1993. Res Immunol. 144: 606-9. PMID: 7905653
- A soluble form of the human CD8 alpha chain expressed in the baculovirus system: biochemical characterization and binding to MHC class I. | Alcover, A., et al. 1993. Mol Immunol. 30: 55-67. PMID: 8417375
- Human CD8 alpha expression in NK cells but not cytotoxic T cells of transgenic mice. | Kieffer, LJ., et al. 1996. Int Immunol. 8: 1617-26. PMID: 8921442
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD8-α Antibody (0.N.66) | sc-70791 | 200 µg/ml | $322.00 | |||
CD8-α Antibody (0.N.66): m-IgG Fc BP-HRP Bundle | sc-539311 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD8-α Antibody (0.N.66): m-IgG1 BP-HRP Bundle | sc-541400 | 200 µg Ab; 20 µg BP | $361.00 |