CD203c Antibody (1G11): sc-293363

CD203c Antibody (1G11) is a mouse monoclonal IgG2a kappa light chain antibody that detects CD203c of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CD203c antibody (1G11) is available as a non-conjugated format. CD203c, also known as ecto-nucleotide pyrophosphatase/phospho-diesterase-3, plays a crucial role in regulating extracellular nucleotide levels, which is essential for various cellular processes, including inflammation and cell signaling. CD203c is primarily located on the surface of basophils, a type of immune cell that is pivotal in mediating allergic responses and other inflammatory conditions. CD203c expression is significantly upregulated in response to allergens such as cat dander, latex, and insect venoms, making CD203c a valuable marker for diagnosing allergic reactions. Additionally, CD203c has been implicated in tumor biology, as CD203c upregulation may serve as a potential tumor marker for colon carcinoma, highlighting CD203c importance not only in allergy but also in cancer research. CD203c monoclonal antibody (1G11)′s ability to effectively detect CD203c in various applications makes CD203c (1G11) antibody an essential tool for researchers studying immune responses and tumor biology.

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CD203c Antibody (1G11) References:

1. Individual hymenoptera venom compounds induce upregulation of the basophil activation marker ectonucleotide pyrophosphatase/phosphodiesterase 3 (CD203c) in sensitized patients.  |  Binder, M., et al. 2002. Int Arch Allergy Immunol. 129: 160-8. PMID: 12403934
2. Cerivastatin and atorvastatin inhibit IL-3-dependent differentiation and IgE-mediated histamine release in human basophils and downmodulate expression of the basophil-activation antigen CD203c/E-NPP3.  |  Majlesi, Y., et al. 2003. J Leukoc Biol. 73: 107-17. PMID: 12525568
3. Marked improvement of the basophil activation test by detecting CD203c instead of CD63.  |  Boumiza, R., et al. 2003. Clin Exp Allergy. 33: 259-65. PMID: 12580920
4. Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli.  |  Grönlund, H., et al. 2003. J Biol Chem. 278: 40144-51. PMID: 12732623
5. Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma.  |  Yano, Y., et al. 2003. Int J Mol Med. 12: 763-6. PMID: 14533006