Calpain 1 Antibody (P-6): sc-81171

Calpain 1 Antibody (P-6) is a mouse monoclonal IgG1 antibody that detects Calpain 1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Calpain 1, also known as µ-calpain, is a crucial intracellular calcium-dependent protease that plays a significant role in the cleavage of cytoskeletal and submembranous proteins, thereby influencing essential cellular processes such as cell fusion, mitosis, and meiosis. Calpain 1 exists as a heterodimer composed of a small regulatory subunit and a large catalytic subunit, which is vital for enzymatic activity. Calpastatin regulates Calpain 1 by inhibiting proteolytic activity and membrane binding, highlighting the importance of post-translational modifications in modulating function. This regulation is critical in various physiological contexts, including spermatogenesis and the acrosome reaction, where precise control of proteolytic activity is necessary for successful fertilization. Calpain 1 has been shown to co-localize with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain, suggesting involvement in neuroinflammatory processes. anti-Calpain 1 antibody (P-6) serves as an essential tool for researchers studying the intricate roles of this protease in cellular dynamics and disease mechanisms.

The preferred Calpain 1 antibody is Calpain 1 Antibody (D-11): sc-271313.