cadherin-23 Antibody (A-5): sc-166067
- cadherin-23 Antibody (A-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 151-450 mapping within an extracellular domain of cadherin-23 of human origin
- recommended for detection of cadherin-23 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for cadherin-23 Antibody (A-5) for WB applications. These reagents are now offered in bundles with cadherin-23 Antibody (A-5) (see ordering information below).
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SEE ALSO...
cadherin-23 Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects cadherin-23 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cadherin-23 plays a crucial role in cell adhesion and is essential for proper functioning of hair cells in the inner ear, where cadherin-23 contributes to the formation of a functional network during hair cell differentiation. Cadherin-23′s location at the cell membrane facilitates interaction with other proteins, such as myosin VIIIa and harmonin, which are necessary for maintaining structural integrity and functionality of hair cells. Mutations in cadherin-23′s extracellular calcium-binding domain can lead to Usher syndrome type 1D, a genetic disorder characterized by hearing loss, balance issues, and progressive vision loss due to retinitis pigmentosa. Multiple cadherin-23 splice variants further complicate the disease phenotype, highlighting the importance of understanding cadherin-23′s structure and interactions for potential therapeutic interventions. anti-cadherin-23 antibody (A-5) serves as an invaluable tool for researchers studying molecular mechanisms underlying these conditions and cadherin-23′s role in cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cadherin-23 Antibody (A-5) | sc-166067 | 200 µg/ml | $322.00 | |||
cadherin-23 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-540006 | 200 µg Ab; 10 µg BP | $361.00 | |||
cadherin-23 Antibody (A-5): m-IgG1 BP-HRP Bundle | sc-541840 | 200 µg Ab; 20 µg BP | $361.00 |