Bag-1 Antibody (3.9F1E11): sc-56004
- Bag-1 Antibody (3.9F1E11) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against full length Bag-1 of human origin
- recommended for detection of Bag-1 of human origin by WB, IP and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Bag-1 Antibody (3.9F1E11) for WB applications. These reagents are now offered in bundles with Bag-1 Antibody (3.9F1E11) (see ordering information below).
Bag-1 Antibody (3.9F1E11) is a mouse monoclonal IgG1 antibody that detects Bag-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Bag-1 is a critical regulator of apoptosis, functioning as a Bcl-2-binding protein that enhances the protective effects of Bcl-2 against cell death. This interaction suggests that Bag-1 may play a significant role in modulating apoptotic pathways, particularly in contexts where Bcl-2 is involved. Bag-1 can influence the balance between cell survival and death, making Bag-1 an important factor in various physiological and pathological processes, including cancer progression and response to therapy. By understanding the dynamics of Bag-1 and Bag-1′s interactions with Bcl-2, researchers can gain insights into the mechanisms of apoptosis and potentially identify new therapeutic targets for diseases characterized by dysregulated cell death. Anti-Bag-1 antibody (3.9F1E11) serves as an essential tool for studying these complex cellular processes and their implications in human health.
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Bag-1 Antibody (3.9F1E11) References:
- BAG-1 accelerates cell motility of human gastric cancer cells. | Naishiro, Y., et al. 1999. Oncogene. 18: 3244-51. PMID: 10359530
- The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription. | Cutress, RI., et al. 2003. Oncogene. 22: 4973-82. PMID: 12902980
- BAG-1 haplo-insufficiency impairs lung tumorigenesis. | Götz, R., et al. 2004. BMC Cancer. 4: 85. PMID: 15560850
- BAG-1 induces autophagy for cardiac cell survival. | Gurusamy, N., et al. 2009. Autophagy. 5: 120-1. PMID: 19001866
- BAG-1 overexpression attenuates luminal apoptosis in MCF-10A mammary epithelial cells through enhanced RAF-1 activation. | Anderson, LR., et al. 2010. Oncogene. 29: 527-38. PMID: 19881545
- Expression of BAG-1 and PARP-1 in precursor lesions and invasive cervical cancer associated with human papillomavirus (HPV). | Hassumi-Fukasawa, MK., et al. 2012. Pathol Oncol Res. 18: 929-37. PMID: 22454210
- Modulation of BAG-1 expression alters the sensitivity of breast cancer cells to tamoxifen. | Liu, H., et al. 2014. Cell Physiol Biochem. 33: 365-74. PMID: 24557447
- Expression and role of BAG-1 in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps. | Lin, D., et al. 2014. Inflammation. 37: 1912-8. PMID: 24830325
- A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells. | Papadakis, E., et al. 2016. Oncotarget. 7: 18851-64. PMID: 26958811
- miR‑494‑BAG‑1 axis is involved in cinobufacini‑induced cell proliferation and apoptosis in gastric cancer. | Shen, Z., et al. 2018. Mol Med Rep. 17: 7435-7441. PMID: 29568970
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bag-1 Antibody (3.9F1E11) | sc-56004 | 200 µg/ml | $322.00 | |||
Bag-1 Antibody (3.9F1E11): m-IgG Fc BP-HRP Bundle | sc-537088 | 200 µg Ab; 10 µg BP | $361.00 | |||
Bag-1 Antibody (3.9F1E11): m-IgGκ BP-HRP Bundle | sc-534275 | 200 µg Ab; 40 µg BP | $361.00 | |||
Bag-1 Antibody (3.9F1E11): m-IgG1 BP-HRP Bundle | sc-544995 | 200 µg Ab; 20 µg BP | $361.00 |