ATAD3B Antibody (A-8): sc-514615

ATAD3B Antibody (A-8) is a mouse monoclonal IgM antibody that detects ATAD3B of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-ATAD3B antibody (A-8) is available in a non-conjugated form, allowing for versatile applications in various experimental settings. ATAD3B is a member of the AAA ATPase family, characterized by a highly conserved AAA domain crucial for ATPase activity. ATAD3B plays a significant role in mitochondrial function, particularly in stabilizing nucleoids, which are essential for maintaining mitochondrial DNA integrity and organization. ATAD3B functions are vital for cellular processes such as organelle biogenesis and vesicle-mediated protein transport, which are critical for cellular homeostasis and energy production. ATAD3B has been implicated in the transformation pathway and chemosensitivity of oligodendrogliomas, highlighting potential relevance in cancer biology. Three isoforms of ATAD3B arise from alternative splicing, contributing to diverse functional roles within the cell.

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ATAD3B Antibody (A-8) References:

1. AAA+ superfamily ATPases: common structure--diverse function.  |  Ogura, T. and Wilkinson, AJ. 2001. Genes Cells. 6: 575-97. PMID: 11473577
2. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.  |  Ye, Y., et al. 2001. Nature. 414: 652-6. PMID: 11740563
3. Evolutionary history and higher order classification of AAA+ ATPases.  |  Iyer, LM., et al. 2004. J Struct Biol. 146: 11-31. PMID: 15037234
4. New insights into the evolution of chromosome 1.  |  Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
5. [Structure, function and mechanisms of action of ATPases from the AAA superfamily of proteins].  |  Kedzierska, S. 2006. Postepy Biochem. 52: 330-8. PMID: 17201069
6. The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.  |  He, J., et al. 2007. J Cell Biol. 176: 141-6. PMID: 17210950
7. ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties.  |  Hubstenberger, A., et al. 2008. Exp Cell Res. 314: 2870-83. PMID: 18639545
8. The AAA team: related ATPases with diverse functions.  |  Patel, S. and Latterich, M. 1998. Trends Cell Biol. 8: 65-71. PMID: 9695811
9. AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes.  |  Neuwald, AF., et al. 1999. Genome Res. 9: 27-43. PMID: 9927482

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ATAD3B Antibody (A-8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-ATAD3B Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ATAD3B Antibody (A-8) Specifications

Alternate Product Name: ATAD3B

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 598-615

Epitope Target: ATAD3B

Epitope Species: human

Product Reactivity/Detection: ATAD3B isoforms 1 and 3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for ATAD3B Antibody (A-8): P: Blocking Peptide

The preferred ATAD3A/B/C antibody is ATAD3A/B/C Antibody (A-4): sc-376185.