AKAP 149 Antibody (H-8): sc-390072
- AKAP 149 Antibody (H-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 604-903 mapping at the C-terminus of AKAP 149 of human origin
- recommended for detection of AKAP 149 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for AKAP 149 Antibody (H-8) for WB applications. These reagents are now offered in bundles with AKAP 149 Antibody (H-8) (see ordering information below).
AKAP 149 Antibody (H-8) is a mouse monoclonal IgG1 antibody that detects AKAP 149 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AKAP 149 plays a crucial role in the spatial organization of protein kinase A (PKA) signaling by anchoring the RII regulatory subunit of PKA to specific cellular locations, thereby ensuring precise signaling pathways are activated in response to various stimuli. This compartmentalization is vital for maintaining the specificity of PKA activity, as it allows for localized phosphorylation of substrates, which is essential for numerous cellular processes, including gene expression, cell growth, and metabolism. The interaction of AKAP 149 with other proteins, such as MAP2 and AKAP 79, highlights its importance in neuronal signaling and the regulation of RNA processing, making AKAP 149 a significant player in both neuronal function and broader cellular dynamics. Anti-AKAP 149 antibody (H-8) enables researchers to explore the intricate mechanisms of PKA signaling and its implications in health and disease.
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AKAP 149 Antibody (H-8) References:
- Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly. | Steen, RL., et al. 2000. J Cell Biol. 150: 1251-62. PMID: 10995432
- AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase. | Furusawa, M., et al. 2001. J Biol Chem. 276: 36647-51. PMID: 11483602
- AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase. | Steen, RL., et al. 2003. J Cell Sci. 116: 2237-46. PMID: 12697839
- Association of PP1 with its regulatory subunit AKAP149 is regulated by serine phosphorylation flanking the RVXF motif of AKAP149. | Küntziger, T., et al. 2006. Biochemistry. 45: 5868-77. PMID: 16669629
- AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. | Lemay, J., et al. 2008. J Mol Biol. 383: 783-96. PMID: 18786546
- Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network. | Rogne, M., et al. 2009. Hum Mol Genet. 18: 978-87. PMID: 19074462
- Role of AKAP 149-PKA-PDE4A complex in cell survival and cell differentiation processes. | Fernández-Araujo, A., et al. 2014. Int J Biochem Cell Biol. 53: 89-101. PMID: 24813785
- A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury. | Soundararajan, R., et al. 2022. Front Pharmacol. 13: 980723. PMID: 36263130
- Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells. | Lin, RY., et al. 1995. J Biol Chem. 270: 27804-11. PMID: 7499250
- Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain. | Trendelenburg, G., et al. 1996. Biochem Biophys Res Commun. 225: 313-9. PMID: 8769136
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AKAP 149 Antibody (H-8) | sc-390072 | 200 µg/ml | $322.00 | |||
AKAP 149 Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-538060 | 200 µg Ab; 10 µg BP | $361.00 | |||
AKAP 149 Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-535587 | 200 µg Ab; 40 µg BP | $361.00 | |||
AKAP 149 Antibody (H-8): m-IgG1 BP-HRP Bundle | sc-545504 | 200 µg Ab; 20 µg BP | $361.00 |