Ah Receptor Antibody (C-4): sc-74572

Ah Receptor Antibody (C-4) is a mouse monoclonal IgG2b antibody that detects Ah Receptor in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Ah Receptor, also known as aromatic hydrocarbon receptor (AhR), plays a crucial role in mediating biological responses to environmental toxins, particularly 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). AhR (C-4) antibody recognizes a protein that functions as a ligand-dependent transcription factor regulating gene expression involved in xenobiotic metabolism and cellular responses to environmental stressors. Upon binding to TCDD or other ligands, Ah Receptor translocates to the nucleus, forming a complex with Ah Receptor nuclear translocator (Arnt). This complex then binds to specific DNA sequences known as xenobiotic responsive elements (XREs), leading to transcriptional activation of target genes. Anti-AhR antibody (C-4) serves as an essential tool for studying mechanisms of action of TCDD and other environmental pollutants, as well as their impact on human health, given Ah Receptor′s vital role in maintaining cellular homeostasis and protecting against toxic insults.

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Ah Receptor Antibody (C-4) References:

1. Ligand binding and activation of the Ah receptor.  |  Denison, MS., et al. 2002. Chem Biol Interact. 141: 3-24. PMID: 12213382
2. Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention.  |  Köhle, C. and Bock, KW. 2006. Biochem Pharmacol. 72: 795-805. PMID: 16780804
3. Genetic and molecular analysis of the Ah receptor and of Cyp1a1 gene expression.  |  Hankinson, O., et al. 1991. Biochimie. 73: 61-6. PMID: 1851644
4. Ah-receptor-independent stimulation of hepatoma 27 culture cell proliferation by polycyclic aromatic hydrocarbons.  |  Volkov, MS., et al. 2012. Biochemistry (Mosc). 77: 201-7. PMID: 22348481
5. Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes.  |  Carreira, VS., et al. 2015. Toxicol Sci. 147: 425-35. PMID: 26139165
6. Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs.  |  Jackson, DP., et al. 2015. Toxicol Res (Camb). 4: 1143-1158. PMID: 26783425
7. From dioxin toxicity to putative physiologic functions of the human Ah receptor in homeostasis of stem/progenitor cells.  |  Bock, KW. 2017. Biochem Pharmacol. 123: 1-7. PMID: 27349986
8. Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis.  |  Murray, IA. and Perdew, GH. 2017. Curr Opin Toxicol. 2: 15-23. PMID: 28944314
9. Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression.  |  Safe, S. and Krishnan, V. 1995. Arch Toxicol Suppl. 17: 99-115. PMID: 7786196
10. The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds.  |  Okey, AB., et al. 1994. Toxicol Lett. 70: 1-22. PMID: 8310450

The preferred Ah Receptor antibody is Ah Receptor Antibody (A-3): sc-133088.