Date published: 2026-8-17

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Adrenochrome (CAS 54-06-8)

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Alternate Names:
3-Hydroxy-1-methyl-5,6-indolinedione; 2,3-dihydro-3-hydroxy-1-methyl-1H-indole-5,6-dione
Application:
Adrenochrome is an inhibitor of catechol-o-methyltransferase
CAS Number:
54-06-8
Molecular Weight:
179.17
Molecular Formula:
C9H9NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Adrenochrome is an oxidation product of adrenaline (ephinephrine, norepinephrine). It inhibits COMT (Catechol-O-methyltransferase), promotes the synthesis of prostaglandins in brain tissue in vitro, promotes the secretion of nerve growth factor by L-M ce.


Adrenochrome (CAS 54-06-8) References

  1. Oxidation process of adrenaline in freshly isolated rat cardiomyocytes: formation of adrenochrome, quinoproteins, and GSH adduct.  |  Costa, VM., et al. 2007. Chem Res Toxicol. 20: 1183-91. PMID: 17630707
  2. Neonatal exposure to estradiol valerate programs ovarian sympathetic innervation and follicular development in the adult rat.  |  Sotomayor-Zárate, R., et al. 2008. Biol Reprod. 78: 673-80. PMID: 18077802
  3. Neuroprotective Properties of Quinone Reductase 2 Inhibitor M-11, a 2-Mercaptobenzimidazole Derivative.  |  Voronin, MV., et al. 2021. Int J Mol Sci. 22: PMID: 34884863
  4. Anti-Obesity Actions of Two Separated Aqueous Extracts From Arbutus (Arbutus unedo) and Hawthorn (Crataegus monogyna) Fruits Against High-Fat Diet in Rats via Potent Antioxidant Target.  |  Wahabi, S., et al. 2023. Dose Response. 21: 15593258231179904. PMID: 37275393
  5. Effect of neonatal melatonin administration on behavioral and brain electrophysiological and redox imbalance in rats.  |  Araújo, AO., et al. 2023. Front Neurosci. 17: 1269609. PMID: 37901423
  6. Prophylactic Coloprotective Effect of Urtica dioica Leaves against Dextran Sulfate Sodium (DSS)-Induced Ulcerative Colitis in Rats.  |  Dakhli, N., et al. 2023. Medicina (Kaunas). 59: PMID: 38004039
  7. Regulatory effect of bacterial melanin on the isoforms of new superoxide-producing associates from rat tissues in rotenone-induced Parkinson's disease.  |  Danielyan, M., et al. 2023. BMC Neurosci. 24: 69. PMID: 38124101
  8. Sex-dependent effect of sublethal copper concentrations on de novo cholesterol synthesis in astrocytes and their possible links to variations in cholesterol and amyloid precursor protein levels in neuronal membranes.  |  Zubillaga, M., et al. 2024. Biol Sex Differ. 15: 4. PMID: 38191520
  9. Methanol Crude Peel Extract of P. granatum Prevents Oxidative Damage in Kidneys of Rats Exposed to Highly Active Antiretroviral Therapy.  |  Kwizera, E., et al. 2024. J Exp Pharmacol. 16: 1-11. PMID: 38213945
  10. Phytochemical Properties of Crataegus azarolus Berries Decoction Extract and Evaluation of its Protective Activity Against Acetic Acid-Induced Ulcerative Colitis in Rats.  |  Sammari, H., et al. 2024. Dose Response. 22: 15593258241226890. PMID: 38223297
  11. 24-Epibrassinolide Reduces Drought-Induced Oxidative Stress by Modulating the Antioxidant System and Respiration in Wheat Seedlings.  |  Avalbaev, A., et al. 2024. Plants (Basel). 13: PMID: 38256702
  12. Neuroprotective potential of Afzelin: A novel approach for alleviating catalepsy and modulating Bcl-2 expression in Parkinson's disease therapy.  |  Alharthy, KM., et al. 2024. Saudi Pharm J. 32: 101928. PMID: 38261905
  13. Detection of epinephrine using a K2Fe4O7 modified glassy carbon electrode.  |  Jiang, M., et al. 2024. RSC Adv. 14: 15408-15412. PMID: 38741971

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Adrenochrome, 25 mg

sc-206029
25 mg
$122.00

Adrenochrome, 250 mg

sc-206029A
250 mg
$490.00