ADAMTS-L4 Antibody (H-9): sc-390187
- ADAMTS-L4 Antibody (H-9) is a mouse monoclonal IgG1 κ ADAMTS-L4 antibody provided at 200 µg/ml
- raised against amino acids 586-835 mapping within an internal region of ADAMTS-L4 of human origin
- ADAMTS-L4 Antibody (H-9) is recommended for detection of ADAMTS-L4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ADAMTS-L4 Antibody (H-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ADAMTS-L4 Antibody (H-9) for WB applications. These reagents are now offered in bundles with ADAMTS-L4 Antibody (H-9) (see ordering information below).
ADAMTS-L4 Antibody (H-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects ADAMTS-L4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADAMTS-L4 (H-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ADAMTS-L4, also known as TSRC1 (Thrombospondin repeat-containing protein 1), is a 1,074 amino acid secreted protein that plays a crucial role in regulating apoptosis, making ADAMTS-L4 significant in the context of various diseases, including cancer. ADAMTS-L4 interacts with cathepsin B, which is involved in protein degradation and has implications in tumor progression and metastasis. Expression of ADAMTS-L4 in tissues such as the spleen, liver, skeletal muscle, lung, colon, testis, placenta, heart, and leukocytes highlights ADAMTS-L4′s importance in diverse biological processes and potential as a therapeutic target. Mutations in ADAMTS-L4 can lead to autosomal recessive isolated ectopia lentis, a rare condition characterized by the displacement of the lens due to defective zonule formation. With multifaceted roles and interactions, ADAMTS-L4 remains a valuable target for research in both normal physiology and pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ADAMTS-L4 Antibody (H-9) References:
- The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development. | Adams, JC. and Tucker, RP. 2000. Dev Dyn. 218: 280-99. PMID: 10842357
- TSRC1, a widely expressed gene containing seven thrombospondin type I repeats. | Buchner, DA. and Meisler, MH. 2003. Gene. 307: 23-30. PMID: 12706885
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. | Liu, T., et al. 2005. J Proteome Res. 4: 2070-80. PMID: 16335952
- Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90. | Liu, J., et al. 2006. FEBS Lett. 580: 245-50. PMID: 16364318
- A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated ectopia lentis. | Ahram, D., et al. 2009. Am J Hum Genet. 84: 274-8. PMID: 19200529
- Confirmation of ADAMTSL4 mutations for autosomal recessive isolated bilateral ectopia lentis. | Greene, VB., et al. 2010. Ophthalmic Genet. 31: 47-51. PMID: 20141359
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ADAMTS-L4 Antibody (H-9) | sc-390187 | 200 µg/ml | $322.00 | |||
ADAMTS-L4 Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-527619 | 200 µg Ab; 10 µg BP | $361.00 | |||
ADAMTS-L4 Antibody (H-9): m-IgG1 BP-HRP Bundle | sc-532992 | 200 µg Ab; 20 µg BP | $361.00 | |||
ADAMTS-L4 Antibody (H-9) AC | sc-390187 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ADAMTS-L4 Antibody (H-9) HRP | sc-390187 HRP | 200 µg/ml | $322.00 | |||
ADAMTS-L4 Antibody (H-9) FITC | sc-390187 FITC | 200 µg/ml | $336.00 | |||
ADAMTS-L4 Antibody (H-9) PE | sc-390187 PE | 200 µg/ml | $349.00 | |||
ADAMTS-L4 Antibody (H-9) Alexa Fluor® 488 | sc-390187 AF488 | 200 µg/ml | $364.00 | |||
ADAMTS-L4 Antibody (H-9) Alexa Fluor® 546 | sc-390187 AF546 | 200 µg/ml | $364.00 | |||
ADAMTS-L4 Antibody (H-9) Alexa Fluor® 594 | sc-390187 AF594 | 200 µg/ml | $364.00 | |||
ADAMTS-L4 Antibody (H-9) Alexa Fluor® 647 | sc-390187 AF647 | 200 µg/ml | $364.00 | |||
ADAMTS-L4 Antibody (H-9) Alexa Fluor® 680 | sc-390187 AF680 | 200 µg/ml | $364.00 | |||
ADAMTS-L4 Antibody (H-9) Alexa Fluor® 790 | sc-390187 AF790 | 200 µg/ml | $364.00 |