Date published: 2025-12-4

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Chelerythrine chloride (CAS 3895-92-9)

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Alternate Names:
Toddalin chloride
Application:
Chelerythrine chloride is a potent and selective inhibitor of protein kinase C
CAS Number:
3895-92-9
Purity:
≥98%
Molecular Weight:
383.82
Molecular Formula:
C21H18NO4Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Chelerythrine chloride is an isoquinoline alkaloid. It has been reported to be a potent and selective inhibitor of PKC (protein kinase C, IC50=0.66 muM), and an independent activator of MAPK pathways. The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is through the inhibition of binding BclXL to Bax or Bad at an IC50 = 1.5 muM. When used in combination with cisplatin (sc-200896) inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also through inhibition of thromboxane formation and phosphoinositide breakdown chelerythrine chloride was demonstrated to inhibit rabbit platelet aggregation and release. Chelerythrine Chloride is an inhibitor of Cox-2.


Chelerythrine chloride (CAS 3895-92-9) References

  1. Axonal transport is inhibited by a protein kinase C inhibitor in cultured isolated mouse dorsal root ganglion cells.  |  Hiruma, H., et al. 1999. Brain Res. 826: 135-8. PMID: 10216205
  2. Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C.  |  Yu, R., et al. 2000. J Biol Chem. 275: 9612-9. PMID: 10734112
  3. Chelerythrine chloride induces rapid polymorphonuclear leukocyte apoptosis through activation of caspase-3.  |  Sweeney, JF., et al. 2000. Shock. 13: 464-71. PMID: 10847634
  4. Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans.  |  Ko, FN., et al. 1990. Biochim Biophys Acta. 1052: 360-5. PMID: 2162213
  5. Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell.  |  Zhang, ZF., et al. 2011. Arch Pharm Res. 34: 791-800. PMID: 21656365
  6. Chelerythrine is a potent and specific inhibitor of protein kinase C.  |  Herbert, JM., et al. 1990. Biochem Biophys Res Commun. 172: 993-9. PMID: 2244923
  7. Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines.  |  Chen, XM., et al. 2016. Oncol Lett. 11: 3917-3924. PMID: 27313717
  8. Chelerythrine Chloride Downregulates β-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma.  |  Heng, WS. and Cheah, SC. 2020. Molecules. 25: PMID: 31935827
  9. Chelerythrine Chloride: A Potential Rumen Microbial Urease Inhibitor Screened by Targeting UreG.  |  Zhang, X., et al. 2021. Int J Mol Sci. 22: PMID: 34360977
  10. Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC/ERK/CREB pathway in an experimental chronic migraine rat model.  |  Tian, R., et al. 2022. J Headache Pain. 23: 35. PMID: 35260079
  11. Chelerythrine Chloride Inhibits Stemness of Melanoma Cancer Stem-Like Cells (CSCs) Potentially via Inducing Reactive Oxygen Species and Causing Mitochondria Dysfunction.  |  Li, H., et al. 2022. Comput Math Methods Med. 2022: 4000733. PMID: 35761835
  12. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.  |  Jarvis, WD., et al. 1994. Cancer Res. 54: 1707-14. PMID: 7511048
  13. Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C.  |  Freemerman, AJ., et al. 1996. Mol Pharmacol. 49: 788-95. PMID: 8622627
  14. Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C.  |  Lee, SK., et al. 1998. J Biol Chem. 273: 19829-33. PMID: 9677417
  15. Inhibition of protein kinase C translocation from cytosol to membrane by chelerythrine.  |  Chao, MD., et al. 1998. Planta Med. 64: 662-3. PMID: 9810275

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Chelerythrine chloride, 5 mg

sc-3547
5 mg
$88.00

Chelerythrine chloride, 25 mg

sc-3547A
25 mg
$311.00