Date published: 2025-12-4

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Sennoside A (CAS 81-27-6)

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Application:
Sennoside A is a mild inhibitor of bovine serum monoamine oxidase
CAS Number:
81-27-6
Molecular Weight:
862.74
Molecular Formula:
C42H38O20
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sennoside A, an anthraquinone glycoside present in the leaves and roots of various Senna plant species. This naturally occurring compound, soluble in water. While the precise mechanism of action of sennoside A remains elusive, it is believed to elicit its effects through multiple pathways.


Sennoside A (CAS 81-27-6) References

  1. Sennoside A drug capped biogenic fabrication of silver nanoparticles and their antibacterial and antifungal activities.  |  Al-Ghamdi, AD., et al. 2020. Saudi Pharm J. 28: 1035-1048. PMID: 32792848
  2. Inhibition behavior of Sennoside A and Sennoside C on amyloid fibrillation of human lysozyme and its possible mechanism.  |  Gao, W., et al. 2021. Int J Biol Macromol. 178: 424-433. PMID: 33662415
  3. Organ Specific Differences in Alteration of Aquaporin Expression in Rats Treated with Sennoside A, Senna Anthraquinones and Rhubarb Anthraquinones.  |  Wang, Z., et al. 2021. Int J Mol Sci. 22: PMID: 34360801
  4. Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl4-induced liver fibrosis.  |  Zhu, H., et al. 2021. Pharmacol Res. 174: 105926. PMID: 34619344
  5. Biochemical Screening of Potent Zika Virus Protease Inhibitors.  |  Coelho, C., et al. 2022. ChemMedChem. 17: e202100695. PMID: 35104396
  6. Herbal Medicines for Constipation and Phytochemical Comparison of Active Components.  |  Ma, Q., et al. 2022. Am J Chin Med. 50: 723-732. PMID: 35331086
  7. Development of a Colloidal Gold Immunochromatographic Strip for the One-Step Evaluation of the Total Content of Rhein and Aloe-Emodin in Rhubarb.  |  Sun, P., et al. 2022. Int J Anal Chem. 2022: 7067245. PMID: 35521627
  8. Application of liquid chromatography-high resolution mass spectrometry and liquid chromatography-tandem mass spectrometry methods to 45 weight loss compounds in health functional food, food, and illegal drug.  |  Lee, JH., et al. 2022. J Sep Sci. 45: 2795-2803. PMID: 35614582
  9. The Effects and Mechanisms of Sennoside A on Inducing Cytotoxicity, Apoptosis, and Inhibiting Metastasis in Human Chondrosarcoma Cells.  |  Le, J., et al. 2022. Evid Based Complement Alternat Med. 2022: 8063497. PMID: 36091590
  10. Determination of Total Sennosides and Sennosides A, B, and A1 in Senna Leaflets, Pods, and Tablets by Two-Dimensional qNMR.  |  Çiçek, SS., et al. 2022. Molecules. 27: PMID: 36364175
  11. Time-dependent laxative effect of sennoside A, the core functional component of rhubarb, is attributed to gut microbiota and aquaporins.  |  Zhang, MM., et al. 2023. J Ethnopharmacol. 311: 116431. PMID: 37003403
  12. Hydroxyanthracene derivates citotoxicity: A differential evaluation between single molecule and whole plant extract.  |  Tinti, L., et al. 2023. Front Plant Sci. 14: 1166075. PMID: 37113593
  13. Review on melanosis coli and anthraquinone-containing traditional Chinese herbs that cause melanosis coli.  |  Zhang, R., et al. 2023. Front Pharmacol. 14: 1160480. PMID: 37214441
  14. Sennoside A restrains TRAF6 level to modulate ferroptosis, inflammation and cognitive impairment in aging mice with Alzheimer's Disease.  |  Li, X., et al. 2023. Int Immunopharmacol. 120: 110290. PMID: 37216800

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sennoside A, 5 mg

sc-258153
5 mg
$84.00

Sennoside A, 50 mg

sc-258153A
50 mg
$161.00

Sennoside A, 100 mg

sc-258153C
100 mg
$279.00

Sennoside A, 250 mg

sc-258153B
250 mg
$449.00

Sennoside A, 500 mg

sc-258153D
500 mg
$809.00

Sennoside A, 1 g

sc-258153E
1 g
$1326.00