Molecular structure of D-Pantethine, CAS Number: 16816-67-4
D-Pantethine (CAS 16816-67-4)
Alternate Names:
Bis(N-pantothenylamidoethyl) disulfide
Application:
D-Pantethine is a form of pantothenic acid or vitamin B5
CAS Number:
16816-67-4
Purity:
≥97%
Molecular Weight:
554.72
Molecular Formula:
C22H42N4O8S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-Pantethine is a dimeric form of D-Pantothenic Acid (sodium salt, sc-278919), which acts as a precursor to Coenzyme A and acyl carrier proteins. It is known that the sulfhydryl group is the metabolically active part of the molecule. Coenzyme A is an essential cofactor in over 70 biological pathways such as fatty acid oxidation, carbohydrate metabolism, and amino acid catabolism. Studies conducted in vitro suggest that D-Pantethine inhibits the activity of aldehyde dehydrogenase, however related metabolites of the compound such as Taurine (sc-202354), D-pantetheine, Coenzyme A and D-pantothenate activate this enzyme.
D-Pantethine (CAS 16816-67-4) References
- The effect of pantethine and ultraviolet-B radiation on the development of lenticular opacity in the emory mouse. | Congdon, NT., et al. 2000. Curr Eye Res. 20: 17-24. PMID: 10611711
- An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment. | Rubio, S., et al. 2006. Plant Physiol. 140: 830-43. PMID: 16415216
- Topical apolipoprotein A-1 may have a beneficial effect on the corneal epithelium in a mouse model of dry eye: a pilot study. | Nyunt, AK., et al. 2008. Eye Contact Lens. 34: 287-92. PMID: 18779669
- The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzyme. | Meriläinen, G., et al. 2008. FEBS J. 275: 6136-48. PMID: 19016856
- Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferase. | Yan, X., et al. 2011. Org Biomol Chem. 9: 1538-46. PMID: 21225062
- D-pantethine has vitamin activity equivalent to d-pantothenic acids for recovering from a deficiency of D-pantothenic acid in rats. | Shibata, K., et al. 2013. J Nutr Sci Vitaminol (Tokyo). 59: 93-9. PMID: 23727638
- Specific antioxidant compounds differentially modulate cytotoxic activity of doxorubicin and cisplatin: in vitro and in vivo study. | Panchuk, R., et al. 2014. Croat Med J. 55: 206-17. PMID: 24891279
- Antioxidants selenomethionine and D-pantethine decrease the negative side effects of doxorubicin in NL/Ly lymphoma-bearing mice. | Panchuk, RR., et al. 2016. Croat Med J. 57: 180-92. PMID: 27106359
- Tissue-protective activity of selenomethionine and D-panthetine in B16 melanoma-bearing mice under doxorubicin treatment is not connected with their ROS scavenging potential. | Panchuk, RR., et al. 2017. Croat Med J. 58: 171-184. PMID: 28409500
- Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression. | Jiang, H., et al. 2022. Cancer Sci. 113: 971-985. PMID: 34939274
- Activation and inhibition of yeast aldehyde dehydrogenase activity by pantethine and its metabolites. | Watanabe, A., et al. 1986. Ann Nutr Metab. 30: 54-7. PMID: 3513690
- Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis. | Liu, D., et al. 2023. J Agric Food Chem.. PMID: 36752740
- Intestinal Transplant Immunology and Intestinal Graft Rejection: From Basic Mechanisms to Potential Biomarkers. | Rumbo, M. and Oltean, M. 2023. Int J Mol Sci. 24: PMID: 36901975
- Pantethine. | . 1998. Altern Med Rev. 3: 379-81. PMID: 9802914
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-Pantethine, 1 g | sc-252658 | 1 g | $42.00 | |||
D-Pantethine, 5 g | sc-252658A | 5 g | $76.00 | |||
D-Pantethine, 10 g | sc-252658B | 10 g | $112.00 | |||
D-Pantethine, 25 g | sc-252658C | 25 g | $204.00 | |||
D-Pantethine, 100 g | sc-252658D | 100 g | $614.00 | |||
D-Pantethine, 250 g | sc-252658E | 250 g | $1336.00 | |||
D-Pantethine, 1 kg | sc-252658F | 1 kg | $4090.00 |