Date published: 2025-10-14

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2-Pyridinecarboxaldehyde (CAS 1121-60-4)

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Alternate Names:
2-Formylpyridine, Picolinaldehyde
CAS Number:
1121-60-4
Purity:
≥99%
Molecular Weight:
107.11
Molecular Formula:
C6H5NO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Pyridinecarboxaldehyde assumes a pivotal role as a foundational component within the synthesis of numerous organic compounds. Notably, it contributes to the creation of 2-aminopyridine, a significant precursor in pharmaceutical synthesis. This compound′s reach extends into the domain of dye synthesis, including the production of the vibrant fluorescent dye fluorescein. Furthermore, its utility encompasses participation in the synthesis of materials like metal-organic frameworks (MOFs). This compound is characterized by its reactivity, enabling a diverse array of chemical reactions. With an acid catalyst, it interacts with various compounds, leading to the formation of diverse products. Moreover, it′s capable of intramolecular reactions, giving rise to cyclic structures, exemplified by the formation of pyridine-2-carboxaldehyde dimer.


2-Pyridinecarboxaldehyde (CAS 1121-60-4) References

  1. Complexation to Fe(II), Ni(II), and Zn(II) of multidentate ligands resulting from condensation of 2-pyridinecarboxaldehyde with alpha,omega-triamines: selective imidazolidine/hexahydropyrimidine ring opening revisited.  |  Bréfuel, N., et al. 2005. Inorg Chem. 44: 8916-28. PMID: 16296847
  2. Selective complexation of 3d metal(II) ions with multidentate and chiral isomers derived from condensation of 2-pyridinecarboxaldehyde with triethylenetetramine.  |  Lee, YM., et al. 2009. Dalton Trans. 126-33. PMID: 19081980
  3. Isoreticular metalation of metal-organic frameworks.  |  Doonan, CJ., et al. 2009. J Am Chem Soc. 131: 9492-3. PMID: 19534523
  4. Cyclic Acetal Formation Between 2-Pyridinecarboxaldehyde and gamma-Hydroxy-alpha,beta-Acetylenic Esters.  |  Osman, S. and Koide, K. 2008. Tetrahedron Lett. 49: 6550-6552. PMID: 19907635
  5. Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation.  |  Filak, LK., et al. 2013. Organometallics. 32: 903-914. PMID: 23431223
  6. Synthesis, characterization, fluorescence and catalytic activity of some new complexes of unsymmetrical Schiff base of 2-pyridinecarboxaldehyde with 2,6-diaminopyridine.  |  Ali, OA., et al. 2015. Spectrochim Acta A Mol Biomol Spectrosc. 144: 99-106. PMID: 25748987
  7. N-terminal specific conjugation of extracellular matrix proteins to 2-pyridinecarboxaldehyde functionalized polyacrylamide hydrogels.  |  Lee, JP., et al. 2016. Biomaterials. 102: 268-76. PMID: 27348850
  8. Novel 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes with a high antiproliferative activity by promoting apoptosis and inhibiting cell cycle.  |  Qi, J., et al. 2017. Eur J Med Chem. 134: 34-42. PMID: 28395152
  9. Cytosolic Delivery of Proteins Using Amphiphilic Polymers with 2-Pyridinecarboxaldehyde Groups for Site-Selective Attachment.  |  Sangsuwan, R., et al. 2019. J Am Chem Soc. 141: 2376-2383. PMID: 30663873
  10. Memantine-Derived Schiff Bases as Transdermal Prodrug Candidates.  |  Araujo de Oliveira, AP., et al. 2022. ACS Omega. 7: 11678-11687. PMID: 35449959
  11. Single-Step N-Terminal Modification of Proteins via a Bio-Inspired Copper(II)-Mediated Aldol Reaction.  |  Hanaya, K., et al. 2022. Chemistry. 28: e202201677. PMID: 35723525
  12. Sustainable Coordination Polymer-Based Catalyst and Its Application in the Nitroaromatic Hydrogenation under Mild Conditions.  |  Aghajani, S. and Mohammadikish, M. 2022. Langmuir. 38: 8686-8695. PMID: 35802934
  13. PBC, an easy and efficient strategy for high-throughput protein C-terminome profiling.  |  Zhai, L., et al. 2022. Front Cell Dev Biol. 10: 995590. PMID: 36120566

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Pyridinecarboxaldehyde, 25 g

sc-225541
25 g
$41.00

2-Pyridinecarboxaldehyde, 100 g

sc-225541A
100 g
$82.00

2-Pyridinecarboxaldehyde, 250 g

sc-225541B
250 g
$173.00

2-Pyridinecarboxaldehyde, 1 kg

sc-225541C
1 kg
$632.00

2-Pyridinecarboxaldehyde, 2.5 kg

sc-225541D
2.5 kg
$1533.00