Date published: 2025-9-18

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Dihexadecyl phosphate (CAS 2197-63-9)

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Alternate Names:
DHP, Dicetyl phosphate
Application:
Dihexadecyl phosphate is a lipid used for research purposes
CAS Number:
2197-63-9
Purity:
≥90%
Molecular Weight:
546.85
Molecular Formula:
[CH3(CH2)15O]2P(O)OH
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dihexadecyl phosphate is a phospholipid abundantly present in various organisms and extensively employed in diverse laboratory experiments. This highly hydrophobic and lipophilic compound comprises two long-chain fatty acids and a phosphate group. It assumes a pivotal role in upholding cell membrane integrity and ensuring cellular environment stability. In cell culture applications, Dihexadecyl phosphate improves cellular permeability and membrane function. Additionally, it serves as useful in cell-based assays, facilitating the assessment of cell viability. Mechanistically, Dihexadecyl phosphate heightens cell membrane permeability by binding to the lipids comprising the cell membrane. This augmented permeability fosters efficient transportation of molecules across the membrane, thereby engendering diverse outcomes such as increased cell viability, and augmented cell proliferation.


Dihexadecyl phosphate (CAS 2197-63-9) References

  1. Modeling cell membrane transport: interaction of guanidinylated poly(propylene imine) dendrimers with a liposomal membrane consisting of phosphate-based lipids.  |  Tsogas, I., et al. 2006. Langmuir. 22: 11322-8. PMID: 17154621
  2. Self-assembly of electroactive layer-by-layer films of heme proteins with anionic surfactant dihexadecyl phosphate.  |  Shan, W., et al. 2008. Biophys Chem. 134: 101-9. PMID: 18294752
  3. Nanoliposomes for encapsulation and delivery of the potential antitumoral methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2-carboxylate.  |  Abreu, AS., et al. 2011. Nanoscale Res Lett. 6: 482. PMID: 21812989
  4. Formation of carbonated hydroxyapatite films on metallic surfaces using dihexadecyl phosphate-LB film as template.  |  de Souza, ID., et al. 2014. Colloids Surf B Biointerfaces. 118: 31-40. PMID: 24727116
  5. Assembly and Characterization of HBc Derived Virus-like Particles with Magnetic Core.  |  Rybka, JD., et al. 2019. Nanomaterials (Basel). 9: PMID: 30691173
  6. Bioevaluation of superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with dihexadecyl phosphate (DHP).  |  Mieloch, AA., et al. 2020. Sci Rep. 10: 2725. PMID: 32066785
  7. A comparative study of the permeation of dihexadecyl phosphate vesicles by various carboxylic acids and some of their tetrazole analogues.  |  Pernice, P., et al. 1988. Biophys Chem. 32: 15-20. PMID: 3233310
  8. Preformulation characterization and identification of excipients for nevirapine loaded niosomes.  |  Witika, BA. and Walker, RB. 2021. Pharmazie. 76: 77-83. PMID: 33714283
  9. Glutathione Liposomes Carrying Ceftriaxone, FK506, and Nilotinib to Control Overexpressed Dopamine Markers and Apoptotic Factors in Neurons.  |  Kuo, YC., et al. 2021. ACS Biomater Sci Eng. 7: 3242-3255. PMID: 34189904
  10. Specific Ion Effects in Lanthanide-Amphiphile Structures at the Air-Water Interface and Their Implications for Selective Separation.  |  Yoo, S., et al. 2022. ACS Appl Mater Interfaces. 14: 7504-7512. PMID: 35099919
  11. One-step enzyme-free dual electrochemical immunosensor for histidine-rich protein 2 determination.  |  Dip Gandarilla, AM., et al. 2020. RSC Adv. 11: 408-415. PMID: 35423017
  12. Electrografting a Hybrid Bilayer Membrane via Diazonium Chemistry for Electrochemical Impedance Spectroscopy of Amyloid-β Aggregation.  |  Fini, H., et al. 2022. Micromachines (Basel). 13: PMID: 35457879
  13. In Vitro and In Vivo Evaluation of the Effectiveness and Safety of Amygdalin as a Cancer Therapy.  |  El-Ela, FIA., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 36355478
  14. Evaluating the neuroprotective effect of Spirulina platensis-loaded niosomes against Alzheimer's disease induced in rats.  |  Abdelghany, AK., et al. 2023. Drug Deliv Transl Res.. PMID: 36790720
  15. A study of the permeation of dihexadecyl phosphate vesicles by various anesthetics.  |  Ménassa, PE. and Sandorfy, C. 1986. Biophys Chem. 25: 175-9. PMID: 3814752

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dihexadecyl phosphate, 1 g

sc-214893
1 g
$74.00

Dihexadecyl phosphate, 5 g

sc-214893A
5 g
$312.00