Molecular structure of Chrysophanol, CAS Number: 481-74-3
Chrysophanol (CAS 481-74-3)
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Alternate Names:
Chrysophanic acid; 1,8-Dihydroxy-3-methylanthraquinone
Application:
Chrysophanol is an inducer of intracellular Ca2+ concentration and exhibit antifungal activities
CAS Number:
481-74-3
Purity:
≥98%
Molecular Weight:
254.24
Molecular Formula:
C15H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Chrysophanol is an anthraquinone found in the root of Rheum wittrochii. It may act to increase intracellular Ca2+ concentration and exhibit antifungal activities. Chrysophanol acts by modulating the activity of several enzymes and proteins involved in inflammation, oxidative stress, and cell death. It is also believed to interact with several receptors, including the nuclear factor-kappa B, the cyclooxygenase-2, and the peroxisome proliferator-activated receptor gamma.
Chrysophanol (CAS 481-74-3) References
- Antifungal activity of anthraquinone derivatives from Rheum emodi. | Agarwal, SK., et al. 2000. J Ethnopharmacol. 72: 43-6. PMID: 10967452
- Chrysophanol: A Natural Anthraquinone with Multifaceted Biotherapeutic Potential. | , ., et al. 2019. Biomolecules. 9: PMID: 30781696
- Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics. | Xie, L., et al. 2019. J Pharm Pharmacol. 71: 1475-1487. PMID: 31373015
- Chrysophanol exhibits inhibitory activities against colorectal cancer by targeting decorin. | Deng, M., et al. 2020. Cell Biochem Funct. 38: 47-57. PMID: 31710116
- The pharmacological properties of chrysophanol, the recent advances. | Su, S., et al. 2020. Biomed Pharmacother. 125: 110002. PMID: 32066044
- Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis. | Kuo, CY., et al. 2020. J Pharmacol Sci. 144: 172-182. PMID: 32811746
- Chrysophanol Protects Against Acute Heart Failure by Inhibiting JNK1/2 Pathway in Rats. | Xie, XJ. and Li, CQ. 2020. Med Sci Monit. 26: e926392. PMID: 33044948
- Retraction Note: Chrysophanol suppresses growth and metastasis of T cell acute lymphoblastic leukemia via miR-9/PD-L1 axis. | Yin, J., et al. 2021. Naunyn Schmiedebergs Arch Pharmacol. 394: 571. PMID: 33247764
- Chrysophanol protects human bronchial epithelial cells from cigarette smoke extract (CSE)-induced apoptosis. | Wu, G., et al. 2020. Int J Mol Epidemiol Genet. 11: 39-45. PMID: 33488953
- Chrysophanol Induced Glioma Cells Apoptosis via Activation of Mitochondrial Apoptosis Pathway. | Gu, J., et al. 2021. Bioengineered. 12: 6855-6868. PMID: 34519612
- Chrysophanol exerts a protective effect against sepsis-induced acute myocardial injury through modulating the microRNA-27b-3p/Peroxisomal proliferating-activated receptor gamma axis. | Zhao, H., et al. 2022. Bioengineered. 13: 12673-12690. PMID: 35599576
- Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner. | Xia, P., et al. 2022. Exp Neurol. 357: 114197. PMID: 35932799
- Chrysophanol, a main anthraquinone from Rheum palmatum L. (rhubarb), protects against renal fibrosis by suppressing NKD2/NF-κB pathway. | Gu, M., et al. 2022. Phytomedicine. 105: 154381. PMID: 35988461
- Chrysophanol facilitates long-term neurological recovery through limiting microglia-mediated neuroinflammation after ischemic stroke in mice. | Liu, X., et al. 2022. Int Immunopharmacol. 112: 109220. PMID: 36095949
- A tumor cell growth inhibitor from Polygonum hypoleucum Ohwi. | Kuo, YC., et al. 1997. Life Sci. 61: 2335-44. PMID: 9408056
Inhibitor of:
TP53TG3, and WAVE1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chrysophanol, 25 mg | sc-205631 | 25 mg | $72.00 | |||
Chrysophanol, 100 mg | sc-205631A | 100 mg | $260.00 |