Date published: 2025-10-8

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Kahweol (CAS 6894-43-5)

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See product citations (9)

Application:
Kahweol is an inducer of the detoxifying enzyme, glutathione S-transferase
CAS Number:
6894-43-5
Purity:
≥97%
Molecular Weight:
314.42
Molecular Formula:
C20H26O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Kahweol, a compound found in the oil of coffee beans, is extensively studied within the context of agricultural and environmental chemistry. It represents a key focus in the investigation of the effects of roasting on the chemical composition of coffee, as kahweol undergoes transformation during this process. In the arena of analytical research, kahweol is used as a marker to gauge the purity and presence of coffee oil in various samples, and its stability is also a subject of interest. Moreover, its influence on the flavor profile of coffee has made it a topic of study among food chemists who aim to correlate specific compounds with sensory attributes. In addition, kahweol is examined for its role in the natural defense mechanisms of coffee plants against pests and pathogens.


Kahweol (CAS 6894-43-5) References

  1. Coffee and its consumption: benefits and risks.  |  Butt, MS. and Sultan, MT. 2011. Crit Rev Food Sci Nutr. 51: 363-73. PMID: 21432699
  2. Kahweol inhibits adipogenesis of 3T3-L1 adipocytes through downregulation of PPARγ.  |  Kim, JS., et al. 2018. Nat Prod Res. 32: 1216-1219. PMID: 28508719
  3. Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties.  |  Ren, Y., et al. 2019. Int J Mol Sci. 20: PMID: 31480213
  4. Kahweol Found in Coffee Inhibits IL-2 Production Via Suppressing the Phosphorylations of ERK and c-Fos in Lymphocytic Jurkat Cells.  |  Park, JB. 2021. J Diet Suppl. 18: 433-443. PMID: 32583704
  5. Kahweol Reduces Food Intake of Caenorhabditis elegans.  |  Farias-Pereira, R., et al. 2020. J Agric Food Chem. 68: 9683-9689. PMID: 32786849
  6. Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways.  |  Seo, HY., et al. 2020. PLoS One. 15: e0240478. PMID: 33044988
  7. Kahweol, a Diterpenoid Molecule, Inhibits CTGF-Dependent Synthetic Phenotype Switching and Migration in Vascular Smooth Muscle Cells.  |  Lee, JH., et al. 2021. Molecules. 26: PMID: 33530626
  8. Coffee and Arterial Hypertension.  |  Surma, S. and Oparil, S. 2021. Curr Hypertens Rep. 23: 38. PMID: 34370111
  9. Kahweol Exerts Skin Moisturizing Activities by Upregulating STAT1 Activity.  |  Chen, H., et al. 2021. Int J Mol Sci. 22: PMID: 34445570
  10. Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway.  |  Seo, HY., et al. 2021. Int J Mol Sci. 22: PMID: 34638852
  11. Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation.  |  Guzzo, LS., et al. 2021. Braz J Med Biol Res. 54: e11071. PMID: 34730678
  12. Kahweol Protects against Acetaminophen-Induced Hepatotoxicity in Mice through Inhibiting Oxidative Stress, Hepatocyte Death, and Inflammation.  |  Kim, JY., et al. 2022. Biomed Res Int. 2022: 8121124. PMID: 35265717
  13. Recent Updates on the Functional Impact of Kahweol and Cafestol on Cancer.  |  Eldesouki, S., et al. 2022. Molecules. 27: PMID: 36364160

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Kahweol, 5 mg

sc-203089B
5 mg
$88.00

Kahweol, 10 mg

sc-203089
10 mg
$153.00

Kahweol, 25 mg

sc-203089A
25 mg
$357.00