Molecular structure of Gossypol, CAS Number: 303-45-7
Gossypol (CAS 303-45-7)
See product citations (12)
Alternate Names:
Pogosin; AT101; 2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)
Application:
Gossypol is an inhibitor of PKC, Bcl-2, 5-LO, and 12-LO
CAS Number:
303-45-7
Purity:
≥90%
Molecular Weight:
518.56
Molecular Formula:
C30H30O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gossypol can be found in the seeds, stems, leaves, and roots of cotton plants (genus Gossypium). Gossypol may act to contain antitumor, anitviral, and antioxidant properties. Gossypol is a reversible inhibitor of PP2B (protein phosphatase 2B), mitotic kinesin Eg5, and PKC (protein kinase C). Gossypol also potentially inhibits PAF-R, Bcl-2, 5-LO (5-lipoxygenase), and 12-LO. Gossypol is an inhibitor of Bcl-xl. It has shown potential in vitro against various cancer cell lines by inducing apoptosis and inhibiting cell proliferation. The compound′s ability to inhibit several key enzymes involved in cell growth and survival, including kinases and dehydrogenase enzymes, contributes to its anti-cancer activity.
Gossypol (CAS 303-45-7) References
- Cytotoxic effect of gossypol on colon carcinoma cells. | Wang, X., et al. 2000. Life Sci. 67: 2663-71. PMID: 11105982
- The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway. | Jiang, J., et al. 2004. Anticancer Res. 24: 91-100. PMID: 15015581
- Investigations on gossypol: past and present developments. | Dodou, K., et al. 2005. Expert Opin Investig Drugs. 14: 1419-34. PMID: 16255680
- Gossypol--a polyphenolic compound from cotton plant. | Wang, X., et al. 2009. Adv Food Nutr Res. 58: 215-63. PMID: 19878861
- Recent advances in gossypol derivatives and analogs: a chemistry and biology view. | Lu, Y., et al. 2017. Future Med Chem. 9: 1243-1275. PMID: 28722469
- Gossypol Promotes Wnt/β-Catenin Signaling through WIF1 in Ovariectomy-Induced Osteoporosis. | Liang, J., et al. 2019. Biomed Res Int. 2019: 8745487. PMID: 31139657
- Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer. | Hsieh, YS., et al. 2021. Am J Chin Med. 49: 181-198. PMID: 33371817
- Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells. | Cao, H., et al. 2021. Sci Rep. 11: 5922. PMID: 33723275
- Gossypol Acetic Acid Attenuates Cardiac Ischemia/Reperfusion Injury in Rats via an Antiferroptotic Mechanism. | Lin, JH., et al. 2021. Biomolecules. 11: PMID: 34827665
- A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity. | Gao, Y., et al. 2022. BMC Biol. 20: 143. PMID: 35706035
- Binding of gossypol to purified tubulin and inhibition of its assembly into microtubules. | Medrano, FJ. and Andreu, JM. 1986. Eur J Biochem. 158: 63-9. PMID: 3732269
- Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases. | Hamasaki, Y. and Tai, HH. 1985. Biochim Biophys Acta. 834: 37-41. PMID: 3919771
- Gossypol: a potential antifertility agent for males. | Qian, SZ. and Wang, ZG. 1984. Annu Rev Pharmacol Toxicol. 24: 329-60. PMID: 6375548
- Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle. | Shidaifat, F., et al. 1997. Anticancer Res. 17: 1003-9. PMID: 9137441
Inhibitor of:
β-defensin 110, 12-LO, 1700055N04Rik, 3β-HSD7, 5-LO, Aldehyde Dehydrogenase, ALDH1A1, ALDH1B1, ALDH3A2, ALDH3B1, ALDH3B2, Aldolase A, Aldolase C, allantoicase, AMPKα2, Bcl-2, Bcl-7c, Bcl-B, Bcl-G, Bcl-rambo, Bcl-xl, BCLP, Bfk, BID, c-Erb-A α-2, c-Erb-A β-2, C6orf89, CHST7, CYP11A1, CYP11B1, Cytochrome c, D(−)-Lactate Dehydrogenase, DDX59, DFF-45, DHRS3, DPCR1, E2F-4, EF-1 γ, EG434008, Eg5, Epidermis-type 12-LO, Estradiol, FADD, Gγ4, GOLT1B, HADHA, HAX-1, Heme Oxygenase 3, Hrk, IRG1, karyopherin α7, L-Lactate Dehydrogenase, L3MBTL4, LDH-B, LDHA, LOX, LPAAT-α, LPAAT-β, LRRC1, MBPH, MDH2, NOBOX, NOXA, OATP2A1, oogenesin 2, oogenesin 3, ORP-6, p107, p20-ARC, PAF-R, PDH-E1β, Peroxin 10, PFK-1, PFK-2 car, Pim-3, PKC, PKD, PP2, PUMA, pyridoxal kinase, Rad27, RBM25, RNF135, SCP2, SDF-4, Sec31B, Sec62, Ser/Thr Protein Kinase, SOD-3, SREBP-2, Sva, TMEM41B, TNF-R2, UBE2U, UCRC, Uqcr, UQCRC1, V1RF1, V1RF3, VP16, and YBEY.Activator of:
γ Enolase, ARA70, Bax, Bcl-2, Bcl-B, Bcl-xL, caspase-7, CD30, megalin, PrP, and TRUNDD.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gossypol, 25 mg | sc-200501 | 25 mg | $114.00 | |||
Gossypol, 100 mg | sc-200501A | 100 mg | $225.00 |