ZPK Activators

ZPK, also known as MAP3K12, is involved in the JNK signaling pathway. Chemical compounds that influence the JNK pathway or its upstream regulators can enhance the functional activity of ZPK. For instance, Anisomycin and TNF-α are known activators of the JNK pathway, which could lead to ZPK activation. Sodium Arsenite and Sorbitol, as stressors, also have the potential to activate the JNK pathway and thereby enhance ZPK activity.

Another plausible approach to enhancing ZPK activity is through the modulation of the ERK pathway, which can cross-communicate with the JNK pathway. EGF, known to activate the EGFR/ERK pathway, could indirectly lead to ZPK activation. Similarly, inhibitors of MEK in the ERK pathway, could indirectly enhance ZPK activity by promoting JNK pathway activation. Chemicals that activate PKC, such as PMA and capsaicin, could also lead to ZPK activation, given that PKC can activate the JNK pathway. Lastly, Curcumin, and Quercetin are known to influence SIRT1, JNK, and PI3K pathways respectively, and through these pathways, they could enhance ZPK activity.