ZNF7 Inhibitors
Zinc finger protein 7 (ZNF7), also known as KOX1, is part of the Krüppel-associated box (KRAB) zinc finger protein family. This family is one of the largest groups of transcription factors in mammals and is characterized by the presence of one or more zinc finger domains, which are small, functional, independently folded protein domains stabilized by one or more zinc ions. These domains enable the protein to interact with DNA, RNA, or other proteins.
The defining feature of ZNF7 is its array of C2H2-type zinc fingers. Each zinc finger typically consists of around 30 amino acids and folds into a loop held together by a zinc ion, coordinated by cysteines and histidines. ZNF7 binds to DNA through these zinc finger motifs, and the specific sequence of amino acids within these motifs dictates its binding specificity to certain DNA sequences.Functionally, ZNF7 acts as a transcriptional regulator, meaning it can both activate and repress the transcription of genes. By binding to gene promoters or enhancers, ZNF7 can influence the expression of genes involved in a wide range of cellular processes, including development, differentiation, proliferation, and apoptosis.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
TPEN | 16858-02-9 | sc-200131 | 100 mg | $127.00 | 10 | |
Zinc chelators like TPEN might indirectly affect ZNF7 by altering zinc availability, crucial for the function of zinc finger proteins. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
HDAC inhibitors such as Trichostatin A could indirectly influence ZNF7 by modifying chromatin structure and gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine may affect ZNF7 indirectly by altering gene expression patterns through DNA methylation changes. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
JAK/STAT inhibitors like Ruxolitinib could indirectly impact ZNF7 by modulating pathways involved in gene expression and cell signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, a PI3K/Akt/mTOR inhibitor, might affect ZNF7 indirectly by altering signaling pathways that intersect with DNA binding and gene regulation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
Bromodomain inhibitors like JQ1 may influence ZNF7 indirectly by affecting transcription regulation and chromatin remodeling. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
HSP90 inhibitors like 17-AAG could indirectly influence ZNF7 by affecting protein stability and function. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
Splicing inhibitors such as Pladienolide B may indirectly impact ZNF7 by altering RNA splicing processes. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin, an RNA polymerase inhibitor, could indirectly affect ZNF7 by impacting RNA synthesis and processing. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitors like Bortezomib may influence ZNF7 indirectly by modulating protein degradation pathways. | ||||||