ZNF567 Activators
ZNF567 initiate a variety of intracellular signaling pathways that lead to its phosphorylation and subsequent enhancement of DNA-binding activity. Forskolin, by directly stimulating adenylate cyclase, raises cyclic AMP (cAMP) levels within cells, which in turn activates protein kinase A (PKA). The activation of PKA can phosphorylate ZNF567, enhancing its role as a transcription factor. Similarly, IBMX functions by inhibiting phosphodiesterases, thereby preventing cAMP degradation and sustaining PKA activation, which can also lead to the phosphorylation of ZNF567. PMA, on the other hand, activates protein kinase C (PKC), another kinase that can phosphorylate transcription factors, possibly including ZNF567. Ionomycin, through its role as a calcium ionophore, increases intracellular calcium levels, which can trigger the activation of calcium-dependent protein kinases that may phosphorylate and activate ZNF567.
In addition to these, retinoic acid, by binding to its nuclear receptors, may cooperate with ZNF567 on gene promoters to enhance its activity. Epidermal Growth Factor (EGF), upon binding to its receptor, initiates a cascade involving the MAPK/ERK pathway, which can lead to ZNF567 phosphorylation. Insulin, through its receptor, activates the PI3K/Akt pathway, which could similarly result in the phosphorylation and activation of ZNF567. Lithium chloride inhibits GSK-3, a kinase that phosphorylates and inactivates certain proteins, thus potentially maintaining ZNF567 in an active state. Histone deacetylase inhibitors such as Trichostatin A and Sodium butyrate promote chromatin relaxation, which can enhance the accessibility and function of ZNF567. Anisomycin activates SAPKs/JNKs, which may also lead to the activation of ZNF567. Lastly, Calyculin A inhibits protein phosphatases that normally dephosphorylate proteins, hence it could maintain ZNF567 in a phosphorylated and active form.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can lead to phosphorylation of ZNF567, thereby enhancing its DNA-binding activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, leading to an accumulation of cAMP, which in turn activates PKA. Activation of PKA could phosphorylate ZNF567, enhancing its function in the cell. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), and PKC has been known to phosphorylate various transcription factors. PKC-mediated phosphorylation of ZNF567 could increase its transcriptional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases may phosphorylate ZNF567, enhancing its activity as a transcription factor. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to its nuclear receptors, which can interact with other transcription factors and coactivators, potentially leading to the enhanced transcriptional activity of ZNF567 by cooperative interaction on gene promoters. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the insulin receptor, leading to a cascade through the PI3K/Akt pathway, which may result in the phosphorylation and activation of various transcription factors, possibly including ZNF567. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3), which could prevent the phosphorylation and subsequent inactivation of transcription factors, thereby potentially maintaining ZNF567 in an active state. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, leading to a more relaxed chromatin structure. This can enhance the accessibility of transcription factors like ZNF567 to their target DNA sequences, thereby increasing its activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate also acts as a histone deacetylase inhibitor, promoting chromatin relaxation and potentially enhancing the DNA binding and functional activity of transcription factors such as ZNF567. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases (SAPKs/JNKs), which can lead to the activation of transcription factors. The activation of ZNF567 could be enhanced through this pathway. | ||||||