ZNF358 Activators
ZNF358 play a pivotal role in its functional activation through various molecular mechanisms, primarily via the modulation of the cAMP-PKA signaling pathway. Forskolin, a potent adenylyl cyclase stimulator, directly increases intracellular cAMP levels, leading to the activation of protein kinase A (PKA). PKA then phosphorylates ZNF358, which is a crucial step in its functional activation. Similarly, Isoproterenol, a synthetic catecholamine, and Epinephrine, a natural catecholamine, both bind to beta-adrenergic receptors, triggering a cascade that also culminates in cAMP elevation and PKA activation. Prostaglandin E2 (PGE2), through its interaction with G-protein coupled receptors, and Cholera toxin, by irreversibly activating the Gs alpha subunit, both lead to sustained increases in cAMP levels, further promoting PKA-mediated phosphorylation of ZNF358.
8-Bromo-cAMP and Dibutyryl-cAMP, both of which are cAMP analogs that resist degradation and thereby sustain PKA activation. IBMX and Rolipram, by inhibiting phosphodiesterases that break down cAMP, lead to an accumulation of cAMP within the cell, amplifying PKA activity and subsequent phosphorylation of ZNF358. Zaprinast, though primarily known as a PDE5 inhibitor, can also contribute to elevated cAMP and/or cGMP levels, potentially enhancing PKA activation. Beyond the cAMP-PKA axis, PMA, an activator of protein kinase C (PKC), may initiate alternative phosphorylation pathways, while Anisomycin, by activating JNK and other stress-activated protein kinases, can foster a cellular environment conducive to the activation of ZNF358 through phosphorylation. These chemical activators, by variously influencing the signaling pathways and kinase activities within cells, converge on the common endpoint of ZNF358 phosphorylation and activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, causing an increase in cAMP levels via adenylyl cyclase activation. The rise in cAMP can lead to the activation of PKA, which may then phosphorylate ZNF358, resulting in its functional activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that resists degradation by phosphodiesterases. This chemical can activate PKA, which could phosphorylate ZNF358 and thus lead to its functional activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX, or 3-Isobutyl-1-methylxanthine, is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. By preventing cAMP breakdown, IBMX indirectly increases PKA activity, which could then phosphorylate and activate ZNF358. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, also known as adrenaline, interacts with adrenergic receptors and can increase intracellular cAMP levels, leading to the activation of PKA. PKA can then potentially phosphorylate and activate ZNF358. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its G protein-coupled receptor, leading to an increase in cAMP levels and subsequent activation of PKA, which may phosphorylate ZNF358, leading to its activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK activator which can also activate stress-activated protein kinases (SAPKs). These kinases can influence the activity of transcription factors and other proteins such as ZNF358 by phosphorylation leading to its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate different proteins and could lead to the phosphorylation and activation of ZNF358 as part of a signaling cascade. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that is resistant to degradation by cellular enzymes. It activates PKA which could phosphorylate ZNF358, leading to its functional activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which leads to increased cAMP levels in the cell. The increased cAMP activates PKA which could phosphorylate ZNF358, resulting in its activation. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits phosphodiesterase 5 (PDE5), which can lead to increased cAMP and/or cGMP levels in cells, potentially leading to the activation of PKA and subsequent phosphorylation and activation of ZNF358. | ||||||