ZNF302 Activators
ZNF302 can influence its activity through various biochemical pathways. Forskolin is known to activate adenylate cyclase, which catalyzes the conversion of ATP to cAMP, a secondary messenger with wide-ranging cellular effects. The increase in cAMP levels can then activate protein kinase A (PKA), which is known to phosphorylate various transcription factors. This phosphorylation can lead to changes in the conformation and function of these transcription factors, such as ZNF302, which may enhance their DNA-binding activity and increase transcriptional activity. Similarly, PMA activates protein kinase C (PKC), which phosphorylates serine and threonine residues on many substrates, including transcription factors. The activation of PKC can result in the phosphorylation of ZNF302, modifying its activity as a transcription factor.
Ionomycin raises intracellular calcium levels, which can activate calcium-dependent protein kinases that may phosphorylate ZNF302, thereby influencing its function. Epigallocatechin gallate (EGCG) and Resveratrol can modulate various signaling pathways that impact transcription factors. EGCG may enhance ZNF302's DNA-binding activity, whereas Resveratrol activates the sirtuin pathway, which can affect gene expression by modifying chromatin structure, hence potentially facilitating ZNF302's access to DNA. Spermine, through its modulation of ion channels, can create an intracellular environment that supports the activation of ZNF302. Retinoic acid alters gene expression and cellular differentiation, which may lead to a chromatin context that supports ZNF302 activation. Providing essential cofactors for ZNF302's function, Zinc sulfate supplies zinc ions, crucial for the structural integrity of zinc finger domains within ZNF302, which can directly enhance its DNA-binding capability and activation. Similarly, Dibutyryl-cAMP, a cAMP analog, activates PKA and could have a parallel effect to Forskolin, leading to the activation of ZNF302. Trichostatin A, a histone deacetylase inhibitor, can increase the accessibility of chromatin, allowing ZNF302 better access to its recognition sequences in DNA. Finally, Curcumin, by affecting numerous signaling pathways, can create conditions that promote the transcriptional activity of ZNF302.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing the levels of cyclic AMP (cAMP) within cells. ZNF302, as a transcription factor, could be activated by cAMP-dependent protein kinase (PKA) phosphorylation, altering its function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC) which can lead to the phosphorylation and activation of transcription factors, potentially including ZNF302 by altered phosphorylation states. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially activating calcium-dependent protein kinases which could phosphorylate and activate ZNF302. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is known to influence multiple signaling pathways, including those related to transcription factors. It could enhance ZNF302 DNA binding activity through alterations in cellular signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates the sirtuin pathway which can influence chromatin structure and gene expression, potentially enhancing ZNF302's ability to bind DNA and activate transcription. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that can modulate ion channels and might influence signaling pathways, leading to the activation of ZNF302 by changing the intracellular environment conducive to its function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid affects cellular differentiation and gene expression. Although not directly activating ZNF302, it can prime cellular context for ZNF302 activation through changes in chromatin accessibility. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc sulfate can provide zinc ions, which are essential for the structural integrity of many zinc finger proteins like ZNF302, potentially enhancing its DNA binding activity and functional activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can alter phosphorylation patterns within cells, which may lead to the activation of ZNF302 through secondary signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA. PKA can then phosphorylate transcription factors, which may include ZNF302, leading to its activation. | ||||||