ZNF264 Activators
ZNF264 can engage in various molecular interactions that enhance the protein's ability to bind to DNA, thereby modulating its activity. Zinc pyrithione, for instance, can directly bind to the zinc finger domains of ZNF264, which may induce a structural change that facilitates its DNA binding. Similarly, Bisphenol A can interact with nuclear hormone receptors that, in turn, bind to the promoter regions of ZNF264, thereby increasing its DNA-binding capacity. The action of Trichostatin A, a histone deacetylase inhibitor, can promote hyperacetylation of histones near ZNF264 binding sites, improving the accessibility of the protein to its target sequences. This is complemented by 5-Azacytidine, which reduces DNA methylation levels, possibly relieving repression of ZNF264 target genes and enhancing the protein's activity.
ZNF264 can occur through the stabilization of protein complexes that affect its activity. MG132, by inhibiting proteasome-mediated degradation, can preserve regulatory proteins that boost ZNF264's DNA binding. Sodium butyrate, another histone deacetylase inhibitor, can also lead to histone hyperacetylation, which may improve ZNF264's access to DNA. Specific signaling molecules also play a role; Forskolin raises cAMP levels, potentially enhancing the phosphorylation of proteins associated with ZNF264, while Phorbol 12-myristate 13-acetate activates protein kinase C, which might regulate proteins that control ZNF264 activity. Moreover, compounds like Epigallocatechin gallate can influence signal transduction pathways, affecting transcription factors or coactivators that work with ZNF264. Lithium chloride's inhibition of GSK-3β and the resultant activation of β-catenin can promote ZNF264 activity. Lastly, Resveratrol's modulation of sirtuin activity may lead to chromatin structural changes that facilitate the activation of ZNF264.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc pyrithione can activate ZNF264 by binding to the zinc finger domains, which may induce a conformational change leading to activation of the DNA binding activity of ZNF264. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A, as an endocrine-disrupting chemical, can activate ZNF264 by interacting with nuclear hormone receptors that may then bind to the promoter regions of ZNF264, enhancing its DNA-binding capacity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, an inhibitor of histone deacetylases, can activate ZNF264 by increasing acetylation levels of histones near the DNA-binding sites of ZNF264, which can enhance its ability to bind DNA. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, can activate ZNF264 by reducing methylation levels of DNA, thus relieving repression of genes that ZNF264 targets, leading to increased ZNF264 DNA binding activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132, a proteasome inhibitor, can activate ZNF264 by preventing the degradation of regulatory proteins that interact with ZNF264, thus stabilizing complexes that enhance ZNF264's binding to its target DNA sequences. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, can activate ZNF264 by causing hyperacetylation of histones, which may increase accessibility of ZNF264 to its DNA binding sites and enhance activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can activate ZNF264 by binding to retinoic acid receptors which may interact with ZNF264, leading to allosteric changes that enhance the DNA-binding activity of ZNF264. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase leading to an increase in cAMP levels which can enhance the phosphorylation of proteins that interact with ZNF264, thereby promoting its activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate and thereby regulate proteins that control the activation state of ZNF264, enhancing its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can activate ZNF264 by influencing signal transduction pathways that lead to the activation of transcription factors or coactivators that interact with ZNF264, enhancing its activity. | ||||||