Zfp874 Activators
Zfp874a, a zinc finger protein, is intricately involved in fundamental cellular processes, as predicted by its functions, including DNA-binding transcription factor activity and RNA polymerase II-specific transcriptional regulation. This protein plays a pivotal role in the intricate orchestration of gene expression and the control of various cellular pathways. Orthologous to human ZNF429, Zfp874a exhibits evolutionary conservation of its functions, underscoring its significance across species. The activation of Zfp874a involves a sophisticated interplay of various molecular mechanisms. Through direct activation, certain compounds, such as histone deacetylase (HDAC) inhibitors, promote histone acetylation, thereby enhancing the protein's DNA-binding transcription factor activity. Similarly, DNA demethylating agents directly impact Zfp874a's cis-regulatory region sequence-specific DNA binding activity, contributing to its regulatory functions in RNA polymerase II-specific transcriptional regulation. Beyond direct activation, several compounds exert their influence indirectly. For instance, glycolysis inhibitors and RNA polymerase II inhibitors impact cellular metabolism and transcription processes, respectively, thereby influencing Zfp874a's role in gene expression regulation.
The intricate regulatory network governing Zfp874a activation reflects the complexity of its functions. Bromodomain and extraterminal (BET) inhibitors directly modulate protein-protein interactions, affecting Zfp874a's interaction with BET proteins and, consequently, its activity in RNA polymerase II-specific DNA binding. Other indirect activators, such as those impacting translation processes, histone methylation, and multiple cellular pathways, further contribute to the dynamic regulation of Zfp874a. In summary, the activation of Zfp874a is a nuanced process involving both direct and indirect mechanisms, highlighting its crucial role in transcriptional regulation and gene expression control. The interplay of various compounds underscores the multifaceted nature of Zfp874a's regulatory landscape, positioning it as a central player in fundamental cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase (HDAC) inhibitor, directly activates Zfp874a by promoting histone acetylation. The compound impacts the regulation of transcription by RNA polymerase II by modulating chromatin structure, facilitating Zfp874a's DNA-binding transcription factor activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, directly activates Zfp874a by demethylating DNA. The compound influences the cis-regulatory region sequence-specific DNA binding activity of Zfp874a, allowing it to exert its regulatory functions on RNA polymerase II-mediated transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid, a histone deacetylase (HDAC) inhibitor, directly activates Zfp874a by promoting histone acetylation. The compound modulates the transcriptional regulation by RNA polymerase II, affecting Zfp874a's DNA-binding transcription factor activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose, a glucose analog and glycolysis inhibitor, indirectly activates Zfp874a by influencing cellular metabolism. The compound impacts energy availability, potentially modulating Zfp874a's role in the regulation of transcription by RNA polymerase II. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin, an RNA polymerase II inhibitor, indirectly activates Zfp874a by disrupting RNA synthesis. The compound impacts the availability of RNA polymerase II for transcription, potentially influencing Zfp874a-mediated regulation of transcription by RNA polymerase II. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid, an inhibitor of multiple cellular pathways, indirectly activates Zfp874a by influencing various cellular processes. The compound's pleiotropic effects may impact the cellular milieu, potentially modulating Zfp874a's role in the regulation of transcription by RNA polymerase II. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D, an RNA synthesis inhibitor, indirectly activates Zfp874a by disrupting transcription processes. The compound impacts the availability of RNA polymerase II, potentially influencing Zfp874a's role in the regulation of transcription by RNA polymerase II. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646, a histone acetyltransferase (HAT) inhibitor, directly activates Zfp874a by disrupting acetylation processes. The compound impacts the regulation of transcription by RNA polymerase II, potentially affecting Zfp874a's DNA-binding transcription factor activity. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil (5-FU), a thymidylate synthase inhibitor, indirectly activates Zfp874a by impacting nucleotide synthesis. The compound influences cellular processes, potentially modulating Zfp874a's role in the regulation of transcription by RNA polymerase II. | ||||||