ZDHHC21 Inhibitors

ZDHHC21 Inhibitors belong to a specific chemical class that targets a crucial enzyme in cellular processes known as palmitoyl acyltransferase, specifically the zinc finger DHHC domain-containing 21 enzyme (ZDHHC21). This enzyme is responsible for the addition of palmitate, a lipid molecule, to cysteine residues of substrate proteins, a process known as S-palmitoylation. S-palmitoylation plays a pivotal role in regulating the localization, stability, and function of a myriad of proteins involved in diverse cellular functions, including signal transduction, membrane trafficking, and protein-protein interactions.

ZDHHC21, as a member of the DHHC family, is integral to this palmitoylation mechanism, and its inhibition has been identified as a strategy to modulate cellular processes governed by palmitoylated proteins.ZDHHC21 Inhibitors typically demonstrate selectivity in disrupting the enzymatic activity of ZDHHC21, thereby impeding the palmitoylation of specific target proteins. Researchers and drug developers have focused on elucidating the structural and biochemical aspects of ZDHHC21 Inhibitors to enhance their specificity and efficacy.