Xinβ Activators
Xinβ Activators encompass a variety of chemical compounds that indirectly amplify the functional activity of Xinβ by influencing different signaling pathways or cellular processes related to muscle cell structure and function. For instance, Forskolin and Isoproterenol, through the enhancement of cAMP levels and subsequent activation of PKA, could indirectly contribute to the Xinβ-mediated stabilization of actin filaments and myofibril assembly. Similarly, Dibutyryl-cAMP and Rolipram, by increasing cAMP levels, indirectly promote PKA activity that could positively influence the role of Xinβ in cytoskeletal dynamics. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which is known to impact actin filament dynamics, suggesting a possible enhancement of Xinβ's function inactin filament binding. Y-27632, as a ROCK inhibitor, alters actin cytoskeleton organization, potentially favoring Xinβ's structural role in muscle cells, while Blebbistatin's inhibition of myosin II ATPase may complement Xinβ's function in stabilizing actin filaments. Jasplakinolide's promotion of actin polymerization underscores the importance of actin dynamics for Xinβ activity, as does Calyculin A's inhibition of protein phosphatases, which can lead to a reinforcing effect on the roles of Xinβ in muscle cell cytoarchitecture.
Moreover, Epinephrine functions in a manner akin to Forskolin and Isoproterenol, utilizing β-adrenergic signaling to raise cAMP levels and activate PKA, potentially bolstering Xinβ's involvement in muscle cell structure. Ionomycin, by raising intracellular calcium levels, may activate calcium-dependent pathways that support Xinβ's role in organizing actin filaments within muscle cells. Lastly, ML-7's inhibition of myosin light chain kinase (MLCK) provides an indirect means to enhance Xinβ's role in actin filament stabilization by modulating myosin II activity and muscle contraction mechanics. Collectively, these Xinβ Activators operate through diverse but interconnected biochemical pathways, each contributing to the enhancement of Xinβ's critical functions in the maintenance and regulation of the muscle cell cytoskeleton.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which in turn activates PKA. PKA phosphorylation can lead to changes in cytoskeletal dynamics and muscle contraction, thus potentially enhancing the activity of Xinβ. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a β-adrenergic agonist that, through G protein-coupled receptor signaling, can increase intracellular cAMP and activate PKA. This may enhance Xinβ's role in the structural integrity of cardiac muscle cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can influence actin dynamics. Since Xinβ is associated with actin, PKC activation may indirectly enhance Xinβ's function in actin filament binding. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that penetrates cell membranes and activates PKA. Activation of PKA by this compound can lead to enhanced Xinβ function related to its role in actin filament organization and myofibril assembly. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, leading to an increase in cAMP levels, and subsequently, PKA activation. PKA can phosphorylate targets that impact cytoskeletal organization, possibly enhancing Xinβ activity in muscle cells. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and promotes actin polymerization. By influencing actin dynamics, it may enhance Xinβ's role in the maintenance and organization of the actin cytoskeleton in muscle cells. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a phosphatase inhibitor that can lead to increased phosphorylation of proteins involved in cytoskeletal regulation. This may indirectly enhance Xinβ's function in muscle cell structure and actin filament binding. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, through β-adrenergic receptor activation, increases cAMP levels, leading to PKA activation. PKA can then phosphorylate proteins that affect the cytoskeleton, potentially enhancing the role of Xinβ in muscle cells. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium, which can activate calcium-dependent signaling pathways. This activation may enhance the function of Xinβ in actin filament organization within muscle cells. | ||||||