XAP8 Activators
XAP8, known formally as Remodeling and Spacing Factor 1 (RSF1), is a multifunctional protein integral to the architecture and integrity of chromatin, the complex of DNA and protein found in the nucleus of eukaryotic cells. This protein is a core component of the RSF chromatin-remodeling complex, where it collaborates with SNF2H to modulate the spacing and structure of nucleosomes, which are the fundamental units of chromatin. The dynamic remodeling of chromatin by XAP8 is crucial for a broad range of DNA-dependent processes, including transcription, replication, and repair. The protein's interaction with the hepatitis B virus X protein (HBX) also suggests a specialized role in the lifecycle of this virus, potentially facilitating the transcription of viral genes. XAP8's ubiquity across various tissues underscores its essential function in cellular homeostasis and gene expression regulation.
Research into the molecular biology of XAP8 has revealed that certain chemical compounds can potentially induce its expression. Such activators may hold the key to understanding the intricate regulation of chromatin remodeling. For instance, compounds like Trichostatin A, a known histone deacetylase inhibitor, can create a transcriptionally active chromatin state, possibly leading to the upregulation of genes such as XAP8. Similarly, DNA methyltransferase inhibitors, by altering the epigenetic landscape, could stimulate the expression of XAP8, shedding light on the epigenetic mechanisms that govern its activity. Other compounds, like Forskolin, which increases intracellular cAMP levels, and Retinoic Acid, a ligand for nuclear receptors, could also induce XAP8 expression by promoting the activation of pathways that enhance the transcription of genes. Additionally, natural compounds such as Epigallocatechin gallate, found in green tea, and curcumin, a component of turmeric, have been studied for their ability to influence gene expression profiles, which may include genes like XAP8. These studies provide valuable insights into the complex network of interactions that dictate the expression of essential regulators like XAP8 and highlight the intricate dance between cellular signaling pathways and the expression of genes critical to cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is known to upregulate gene expression by inhibiting histone deacetylase, which could potentially enhance the transcriptional levels of XAP8 by allowing a more open chromatin state conducive to gene activation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
By inhibiting DNA methyltransferase, 5-Aza-2′-Deoxycytidine could stimulate the expression of XAP8 through the hypomethylation of its gene promoter, leading to a transcriptionally permissive state. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin might increase XAP8 expression by elevating intracellular cAMP, thereby activating protein kinase A (PKA) and subsequent transcription factors which target the XAP8 gene promoter. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid could induce upregulation of XAP8 expression through the activation of retinoic acid receptors that bind retinoic acid response elements in gene promoters, including potentially that of XAP8. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate could promote the expression of XAP8 by altering the activity of transcription factors and signaling pathways that govern the transcriptional machinery of the XAP8 gene. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is capable of stimulating XAP8 gene transcription by binding to glucocorticoid response elements present in the promoter region, leading to enhanced gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate may induce the expression of XAP8 by inhibiting histone deacetylase, resulting in a less condensed chromatin structure around the XAP8 gene, thereby promoting transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride could stimulate the expression of XAP8 by inhibiting GSK-3, which can lead to the activation of transcription factors Wnt/β-catenin that may target the XAP8 gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has the potential to stimulate XAP8 expression by activating transcription factors like NF-κB, which can bind to specific sites on the XAP8 gene promoter, promoting its expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might upregulate XAP8 by activating sirtuins that deacetylate histones associated with the XAP8 gene promoter, leading to an increase in gene transcription. | ||||||