WDR73 Activators
WDR73, or WD repeat-containing protein 73, plays a pivotal role in cellular processes through its involvement in the organization and function of protein complexes. This protein, characterized by the presence of WD repeats, a domain implicated in protein-protein interactions, is essential in the regulation of cell cycle, signal transduction, and RNA processing. WDR73's significance is particularly underscored in neural and renal tissues, where it contributes to the development and maintenance of these systems. The function of WDR73 extends to the intricate regulation of cellular architecture and signaling pathways, facilitating the precise coordination of cellular activities necessary for proper cell function and development. The involvement of WDR73 in these fundamental processes highlights its critical role in maintaining cellular homeostasis and responding to environmental cues.
Activation mechanisms of WDR73 are complex and involve a variety of cellular signals and interactions that enhance its functional capacity within cells. These mechanisms can include post-translational modifications such as phosphorylation or ubiquitination, which alter the protein's activity or stability, enabling it to participate effectively in cellular processes. Furthermore, the activation of WDR73 can be mediated by interactions with specific binding partners, which facilitate its incorporation into protein complexes that are vital for cell signaling and structural organization. Such interactions are crucial for the proper localization of WDR73 within the cell, ensuring it is available to participate in the necessary cellular functions. The activation of WDR73 thus plays a fundamental role in regulating cellular processes, with implications for cell growth, differentiation, and response to cellular stress. Through these mechanisms, WDR73 contributes to the dynamic regulation of cellular activities, adapting to the changing needs of the cell and ensuring the maintenance of cellular integrity and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels in cells. Elevated cAMP may enhance WDR73 activity by promoting protein kinase A (PKA) activity, which can phosphorylate proteins involved in WDR73's cellular localization or function, leading to its functional activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, preventing cAMP degradation, thus potentiating cAMP's effects in cells. This indirect mechanism elevates PKA activity, potentially phosphorylating substrates that interact with or regulate WDR73, thereby activating WDR73's functional role in the cell. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram, a selective phosphodiesterase-4 inhibitor, boosts intracellular cAMP levels, indirectly facilitating PKA-mediated phosphorylation events. This cascade may involve phosphorylation of proteins directly interacting with WDR73 or influencing its activation state, enhancing WDR73's cellular functions. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) engages with its receptors, leading to cAMP elevation via G protein-coupled receptor signaling. The resultant PKA activation could phosphorylate regulatory proteins or cofactors of WDR73, thereby promoting its activation and functional engagement in cellular processes. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, directly activates PKA without the need for adenylate cyclase activation, suggesting a potential pathway for WDR73 activation through PKA-mediated phosphorylation of associated regulatory or structural proteins, directly enhancing WDR73 activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, through adrenergic receptors, increases cAMP levels, which in turn activates PKA. PKA could then activate WDR73 by phosphorylating proteins that modulate WDR73's activity or localization, highlighting a potential indirect pathway for WDR73 activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, raises cAMP levels, leading to PKA activation. This could indirectly activate WDR73 by promoting the phosphorylation of proteins involved in its regulatory pathways or direct interaction, facilitating WDR73's cellular role. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Anagrelide increases cAMP levels by inhibiting phosphodiesterase III. The enhanced cAMP/PKA signaling pathway may phosphorylate proteins that interact with or are part of the regulatory network of WDR73, thus activating its function in cellular processes. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine inhibits phosphodiesterase type 1, leading to increased cAMP and PKA activity. This elevation could influence the phosphorylation status of proteins associated with WDR73, potentially activating its functional capacity in the cell. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
Milrinone inhibits phosphodiesterase 3, increasing cAMP levels and subsequently PKA activity. This may lead to the activation of WDR73 through the phosphorylation of proteins that are crucial for WDR73's function or stabilization in the cellular context. | ||||||