VPS28 Activators
VPS28 Activators are compounds that directly or indirectly stimulate the functional activity of VPS28, which is a component of the ESCRT (endosomal sorting complexes required for transport) pathway. VPS28 activators are a specialized group of compounds that target the VPS28 protein, a core component of the Endosomal Sorting Complex Required for Transport-I (ESCRT-I) complex, which is pivotal in the process of membrane remodeling, vesicle trafficking, and endosomal sorting of ubiquitinated proteins. VPS28 is integral to the function of the ESCRT machinery, which is crucial for the degradation of proteins via the lysosome, the budding of viruses from the plasma membrane, and the formation of multivesicular bodies.
The activation of VPS28 can be accomplished through various mechanisms depending on the nature of the chemical activator. Some activators directly engage with VPS28, enhancing its ability to form the ESCRT-I complex or stabilizing its interaction with other ESCRT components, such as VPS37 or MVB12. This direct interaction may alter the conformation of VPS28, facilitating its incorporation into the ESCRT-I complex or bolstering its function within the complex. On the other hand, indirect activators may work by modulating the expression levels of VPS28 or its partner proteins, or by influencing upstream signaling pathways that affect the assembly and disassembly kinetics of the ESCRT complexes. Investigating the role of VPS28 in cellular processes is of great interest, as it is involved in critical pathways such as receptor downregulation, intracellular signaling, and development. By utilizing VPS28 activators, researchers can probe the functional dynamics of the ESCRT machinery, clarify the molecular details of vesicle formation, and understand how cells regulate the sorting of proteins for degradation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of vacuolar-type H+-ATPase (V-ATPase). By inhibiting V-ATPase, it disrupts the acidification of endosomes. This can enhance the activity of VPS28, a component of the endosomal sorting complexes required for transport (ESCRT), by increasing the demand for protein sorting and trafficking through endosomes. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin Sodium is a polyether antibiotic that disrupts intracellular ion transport, particularly in endosomes and lysosomes. Disruption of these processes can indirectly stimulate VPS28 function by increasing the need for protein sorting and trafficking in the ESCRT pathway. | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $45.00 $110.00 $235.00 $6940.00 $26879.00 | 9 | |
Nigericin is an antibiotic that acts as an H+/K+ antiporter. By disrupting proton and potassium gradients across the membranes of endosomes and lysosomes, it can stimulate the function of VPS28 by increasing the demand for protein sorting and trafficking. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is a weak base that accumulates in acidic organelles and raises their pH, disrupting endosomal acidification. This can stimulate VPS28 function by increasing the demand for protein sorting and trafficking. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $61.00 | 8 | ||
Ammonium chloride can raise the pH of acidic intracellular compartments, disrupting endosomal acidification. This can enhance the functional activity of VPS28 by increasing the demand for endosomal protein sorting and trafficking. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that can disrupt calcium homeostasis, which could potentially affect endosomal function and indirectly stimulate the function of VPS28 by increasing the need for protein sorting and trafficking. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a master regulator of cell growth and metabolism. This can indirectly stimulate VPS28 function by altering the demand for protein sorting and trafficking through endosomes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent, irreversible inhibitor of phosphoinositide 3-kinases (PI3Ks), which play key roles in intracellular vesicle transport. Inhibition of PI3Ks can indirectly enhance the activity of VPS28 by altering the demand for protein sorting and trafficking. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
U18666A induces cholesterol accumulation in late endosomes and lysosomes. This disruption can indirectly stimulate VPS28 function by increasing the demand for protein sorting and trafficking in endosomes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can affect multiple cellular processes, including endosomal function. This could stimulate VPS28 function by increasing the need for protein sorting and trafficking. | ||||||