Vmn1r31 Inhibitors
Vmn1r31, a member of the vomeronasal 1 receptor family, plays a crucial role in detecting pheromones and mediating social and reproductive behaviors in rodents. As a G protein-coupled receptor (GPCR), Vmn1r31 is involved in the transduction of signals triggered by pheromone binding, initiating a cascade of intracellular events. The vomeronasal system, comprising Vmn1r31 and other receptors, is integral to the communication of social and reproductive cues among conspecifics. Inhibition of Vmn1r31 involves a diverse range of mechanisms, from directly targeting the receptor to influencing associated pathways crucial for vomeronasal signal transduction. For instance, A987306 directly inhibits the TRPM8 ion channel, which may modulate calcium influx and downstream signaling pathways, influencing Vmn1r31-mediated responses to pheromones. U73122, a PLC inhibitor, directly affects phospholipase C (PLC) activity, a key component in intracellular signaling pathways related to vomeronasal transduction, potentially altering the responsiveness of vomeronasal neurons to Vmn1r31 activation by pheromones.
Additionally, Lidocaine, a sodium channel blocker, disrupts action potential generation in vomeronasal neurons, affecting the transmission of signals initiated by Vmn1r31 activation in response to pheromones. Picrotoxin, a GABAA receptor antagonist, interferes with inhibitory neurotransmission in the vomeronasal system, potentially modulating the responsiveness of vomeronasal neurons to Vmn1r31 activation by pheromones. These mechanisms collectively underscore the complexity of vomeronasal signal processing, shedding light on how chemical modulation can shape social and reproductive behaviors in rodents. Understanding the intricacies of Vmn1r31 inhibition provides valuable insights into the molecular mechanisms governing chemosensory communication in the animal kingdom.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine, a sodium channel blocker, directly inhibits voltage-gated sodium channels. By blocking sodium channels, it interferes with action potential generation in vomeronasal neurons, potentially disrupting the transmission of signals initiated by Vmn1r31 activation in response to pheromones. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $66.00 $280.00 $1300.00 | 11 | |
Picrotoxin, a GABAA receptor antagonist, directly inhibits GABAA receptors. By blocking these receptors, it interferes with inhibitory neurotransmission in the vomeronasal system, potentially modulating the responsiveness of vomeronasal neurons to Vmn1r31 activation by pheromones. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin, a SERCA pump inhibitor, directly influences endoplasmic reticulum calcium levels. Inhibition of SERCA pumps may indirectly impact Vmn1r31, as calcium signaling is integral to vomeronasal transduction, potentially modulating the responsiveness of vomeronasal neurons to Vmn1r31 activation by pheromones. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3 kinase inhibitor, directly affects phosphoinositide 3-kinase (PI3K) activity. Inhibition of PI3K may indirectly impact Vmn1r31, as PI3K is involved in intracellular signaling pathways related to vomeronasal transduction, potentially modulating the responsiveness of vomeronasal neurons to Vmn1r31 activation by pheromones. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM, a calcium chelator, directly influences intracellular calcium levels. Chelation of calcium may indirectly impact Vmn1r31, as calcium signaling is integral to vomeronasal transduction, potentially modulating the responsiveness of vomeronasal neurons to Vmn1r31 activation by pheromones. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF96365, a TRPC channel blocker, directly inhibits transient receptor potential canonical (TRPC) channels. By blocking TRPC channels, it interferes with calcium influx and downstream signaling pathways, potentially influencing Vmn1r31-mediated responses in vomeronasal neurons. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K 8644, a calcium channel activator, directly influences L-type calcium channels. Activation of calcium channels may indirectly impact Vmn1r31, as calcium signaling is integral to vomeronasal transduction, potentially modulating the responsiveness of vomeronasal neurons to Vmn1r31 activation by pheromones. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine, a ryanodine receptor modulator, directly affects intracellular calcium release. Modulation of ryanodine receptors may indirectly impact Vmn1r31, as intracellular calcium signaling is integral to vomeronasal transduction, potentially modulating the responsiveness of vomeronasal neurons to Vmn1r31 activation by pheromones. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine, an adenosine receptor antagonist, directly inhibits adenosine receptors. By blocking these receptors, it interferes with neurotransmission in the vomeronasal system, potentially modulating the responsiveness of vomeronasal neurons to Vmn1r31 activation by pheromones. | ||||||