VGLUT1 Inhibitors
VGLUT1 inhibitors are a specialized class of chemical compounds designed to target and inhibit the activity of the VGLUT1 (Vesicular Glutamate Transporter 1) protein. VGLUT1 is a membrane protein that plays a critical role in the central nervous system by mediating the uptake of glutamate into synaptic vesicles within neurons. Glutamate is the primary excitatory neurotransmitter in the brain, and its proper packaging into vesicles by VGLUT1 is essential for subsequent release into the synaptic cleft. This process is crucial for normal synaptic transmission, as it ensures that sufficient quantities of glutamate are available for signaling between neurons. By inhibiting VGLUT1, these compounds disrupt the normal vesicular storage and release of glutamate, which can influence the overall excitatory signaling in the brain.
The action of VGLUT1 inhibitors typically involves binding to the transporter protein and blocking its function, thereby preventing glutamate from being sequestered into vesicles. This inhibition impairs the ability of neurons to effectively release glutamate during synaptic transmission. The disruption in glutamate transport can lead to a reduction in excitatory neurotransmission, affecting neuronal communication and signaling pathways. Researchers utilize VGLUT1 inhibitors to investigate the role of VGLUT1 in glutamate handling and synaptic function, providing insights into how alterations in this process may affect neural networks and synaptic plasticity. By studying the effects of VGLUT1 inhibition, scientists can better understand the fundamental mechanisms of excitatory neurotransmission and the regulation of glutamate signaling within the central nervous system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may downregulate VGLUT1 expression by inhibiting NF-κB, which is a transcription factor directly involved in the control of neuronal gene expression, including glutamate transporters. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has the potential to lessen VGLUT1 expression by enhancing the deacetylase activity of SIRT1, leading to the suppression of gene transcription in neural tissues. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can decrease VGLUT1 expression by activating retinoic acid receptors, which bind to DNA response elements and alter the transcription of neuronal genes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This compound could reduce VGLUT1 expression by inhibiting key signal transduction enzymes, resulting in a decrease of transcriptional activity of genes involved in glutamate transport. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein has the ability to decrease VGLUT1 expression by inhibiting tyrosine kinases, which play a crucial role in the transcriptional regulation of some neuronal genes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate can lead to the downregulation of VGLUT1 expression by inhibiting histone deacetylation, which causes chromatin to become less accessible for transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone could suppress VGLUT1 expression by activating glucocorticoid receptors, which can bind to promoter regions of genes and decrease their transcriptional activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride might decrease VGLUT1 expression by inhibiting GSK-3 activity, leading to alterations in transcription factor activity relevant to gene expression in neurons. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin can inhibit the translation of VGLUT1 mRNA by specifically inhibiting mTOR, a key regulator of protein synthesis in neurons, thus leading to reduced protein levels. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin can suppress VGLUT1 expression by inhibiting the activity of enzymes responsible for the activation of transcription factors that drive VGLUT1 gene expression. | ||||||