VEGI Inhibitors
VEGI inhibitors are a class of chemical compounds that specifically target and inhibit the activity of Vascular Endothelial Growth Inhibitor (VEGI), a protein known to play a significant role in regulating angiogenesis, the process through which new blood vessels form from pre-existing vessels. VEGI is a member of the tumor necrosis factor (TNF) superfamily, and it primarily acts as an antagonist to angiogenesis, which is crucial for maintaining tissue homeostasis and regulating vascular networks. By inhibiting VEGI, researchers can effectively modulate the angiogenic process, making VEGI inhibitors essential tools for studying the mechanisms of vascular growth and development.
The inhibition of VEGI is particularly useful in research focused on understanding the complex interactions between pro-angiogenic and anti-angiogenic factors. VEGI inhibitors allow scientists to investigate how the suppression of VEGI influences endothelial cell behavior, such as proliferation, migration, and tube formation, which are critical steps in angiogenesis. Moreover, these inhibitors provide insights into the role of VEGI in maintaining the balance between angiogenesis and its inhibition, thereby contributing to a deeper understanding of how this balance affects tissue regeneration, wound healing, and other physiological processes. By using VEGI inhibitors, researchers can also explore the downstream signaling pathways activated or suppressed as a result of VEGI inhibition, further elucidating the molecular underpinnings of angiogenesis regulation. This makes VEGI inhibitors a valuable asset in the study of vascular biology and the broader field of cellular signaling.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is the most abundant catechin in tea and is known for its antioxidant properties. It might modulate TRAIL expression by interacting with various signaling molecules and transcription factors involved in cell survival and apoptosis. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
DIM is a compound found in cruciferous vegetables and is known for its role in supporting detoxification processes. It may inhibit TRAIL expression through its influence on estrogen metabolism and modulation of signaling pathways related to cell proliferation and survival. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone found in soy products, and it has been studied for its role in modulating various cellular processes. It might reduce TRAIL expression by affecting signaling pathways associated with cell growth and apoptosis. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Found in fruits and nuts, ellagic acid is recognized for its antioxidant properties. It might influence TRAIL expression through its effects on inflammation and cellular defense mechanisms. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Derived from milk thistle, silibinin has been researched for its potential liver-protective properties. It may modulate TRAIL expression through its influence on signaling pathways related to liver function and cellular defense. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavonoid found in various fruits and vegetables, known for its antioxidant properties. It might inhibit TRAIL expression by modulating signaling pathways involved in cell survival and apoptosis. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
I3C is a compound found in cruciferous vegetables and is known for its role in detoxification processes. It may modulate TRAIL expression through its effects on estrogen metabolism and cellular defense mechanisms. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib, a proteasome inhibitor, can affect NF-kB signaling, a pathway that is often activated downstream of TWEAK-Fn14 interaction. By inhibiting NF-kB activation, Bortezomib could indirectly inhibit TWEAK signaling. It is also used as a proteasome inhibitor disrupting protein degradation in multiple myeloma and mantle cell lymphoma therapy. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 inhibits the activation of NF-kB. It could indirectly inhibit TWEAK signaling by reducing the activity of this pathway, which is often involved in TWEAK-mediated cellular responses. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide inhibits NF-kB activation and is also known for its anti-inflammatory properties. Its action on NF-kB could lead to indirect inhibition of TWEAK | ||||||