Vaspin Inhibitors
Vaspin, also known as visceral adipose tissue-derived serine protease inhibitor, is a protein primarily associated with adipose tissue regulation and is implicated in the modulation of metabolic homeostasis. Despite being discovered within visceral fat, its expression is not limited to this region and can be found in other tissues, including the skin, liver, and muscle. Vaspin's role in metabolic processes has garnered significant interest in the scientific community, particularly concerning its involvement in the complex network of signals that govern insulin sensitivity and metabolic control. Although the exact mechanisms of vaspin action are not fully understood, it is recognized that vaspin interacts with a variety of cellular pathways that influence the metabolism of glucose and lipids, suggesting a multi-faceted role in energy regulation.
In the quest to further elucidate the functionality of vaspin and its potential regulation, various chemicals have been identified that could play a role in downregulating the expression of this serpin. Compounds such as 5-Azacytidine and Retinoic acid are known to interact with gene promoters and could potentially suppress vaspin expression through changes in DNA methylation and histone modification, respectively. Other agents like Rosiglitazone and Troglitazone, which are PPAR-gamma agonists, could decrease vaspin levels by altering transcriptional activity within adipocytes. Additionally, natural compounds like Epigallocatechin gallate (EGCG) found in green tea, and Curcumin, the active ingredient in turmeric, have been studied for their inhibitory effects on adipocyte differentiation, which could lead to a reduction in vaspin production. These chemicals present a diverse array of molecular structures and properties, each with the potential to contribute to the complex regulation of vaspin, either through direct interaction with the vaspin gene or indirectly via broader metabolic pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine might directly demethylate the promoter region of the vaspin gene, which could lead to transcriptional repression and consequently a reduction in vaspin protein synthesis. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
By activating PPAR-gamma, Rosiglitazone could initiate a cascade of transcriptional events that result in the downregulation of the vaspin gene within adipocytes, leading to decreased vaspin levels. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein could interfere with the epigenetic machinery responsible for the chromatin state of the vaspin gene, potentially leading to a tighter chromatin structure and reduced transcription of the vaspin gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may exert anti-inflammatory actions that specifically lead to the downregulation of inflammatory signaling pathways involved in vaspin gene expression, culminating in a decrease of vaspin secretion. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone could engage PPAR-gamma in adipose tissue, leading to a transcriptional reprogramming that includes the suppression of the vaspin gene's activity, resulting in lower vaspin production. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG could inhibit the differentiation of preadipocytes into adipocytes where vaspin is expressed, leading to a consequent decrease in the adipose tissue's capacity to produce vaspin. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may bind directly to retinoic acid receptors that interact with the vaspin gene promoter, suppressing its activity and leading to a decrease in vaspin expression levels. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
WY-14643 could activate PPAR-alpha, shifting the lipid metabolism of adipocytes in a way that results in decreased necessity for vaspin's function, thus signaling a downregulation of vaspin gene expression. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate's activation of PPAR-alpha could lead to improved lipid profiles and a reduction in the adipose tissue volume, which may signal the body to reduce vaspin gene expression as a consequence of decreased fat mass. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $37.00 | 13 | |
Chrysin's potential to inhibit aromatase could disrupt estrogen synthesis and its associated regulatory effects on adipose tissue, which could be critical in signaling the downregulation of vaspin expression. | ||||||