V5-Probe Inhibitors
The class of compounds referred to as V5-Probe inhibitors includes chemicals that either directly or indirectly modulate the activity of V5-Probe, a tagged protein used for experimental purposes. Among the direct inhibitors, AP20187 acts as a chemical inducer of dimerization (CID), enabling controlled modulation of V5-Probe function by inducing dimerization. Indirect inhibitors, such as bortezomib and MG-132, target protein degradation pathways by inhibiting the proteasome, leading to alterations in the cellular levels and activity of V5-Probe. Autophagy inhibitors, 3-methyladenine and chloroquine, indirectly modulate V5-Probe by suppressing autophagic processes, affecting protein turnover. Wortmannin and LY294002, inhibitors of phosphoinositide 3-kinase (PI3K), disrupt signaling pathways downstream of PI3K, influencing V5-Probe function indirectly. Cycloheximide inhibits protein synthesis, impacting the production of V5-Probe and other proteins. Thapsigargin induces ER stress, affecting cellular processes and modulating V5-Probe function.
Etoposide, a topoisomerase II inhibitor, indirectly influences V5-Probe by disrupting DNA dynamics, causing DNA damage. U0126, a MEK inhibitor, dampens the MAPK/ERK pathway, indirectly influencing V5-Probe function. A769662, an AMP-activated protein kinase (AMPK) activator, indirectly modulates V5-Probe by influencing cellular energy homeostasis and downstream signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, a proteasome inhibitor, indirectly influences V5-Probe by affecting protein degradation pathways. By inhibiting the proteasome, bortezomib can lead to the accumulation of misfolded or unwanted V5-Probe proteins, modulating the overall activity and cellular levels of V5-Probe. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-Methyladenine, an autophagy inhibitor, indirectly modulates V5-Probe activity by suppressing autophagic processes. As autophagy plays a role in protein turnover, inhibiting autophagy with 3-methyladenine can impact the degradation and turnover of V5-Probe, indirectly affecting its cellular levels and activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132, a proteasome inhibitor, indirectly influences V5-Probe by preventing its degradation. By inhibiting the proteasome, MG-132 can lead to the accumulation of V5-Probe proteins, influencing its cellular levels and activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, indirectly modulates V5-Probe activity by disrupting signaling pathways. PI3K is involved in various cellular processes, and inhibiting it with wortmannin can influence downstream pathways that may indirectly impact V5-Probe function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, another PI3K inhibitor, indirectly modulates V5-Probe by disrupting PI3K-dependent signaling pathways. Similar to wortmannin, LY294002 can influence cellular processes downstream of PI3K, potentially impacting V5-Probe function indirectly. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is a protein synthesis inhibitor that indirectly modulates V5-Probe by preventing new protein synthesis. By inhibiting translation, cycloheximide reduces the production of V5-Probe and other proteins, leading to changes in cellular levels and activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is an inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump, indirectly influencing V5-Probe through ER stress. Thapsigargin disrupts calcium homeostasis, leading to ER stress responses that can modulate various cellular processes, potentially affecting the function of V5-Probe. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine, an autophagy inhibitor, indirectly modulates V5-Probe activity by suppressing autophagic processes. As autophagy plays a role in protein turnover, inhibiting autophagy with chloroquine can impact the degradation and turnover of V5-Probe, indirectly affecting its cellular levels and activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, indirectly influences V5-Probe by disrupting DNA dynamics. By inhibiting topoisomerase II, etoposide can cause DNA damage and affect cellular processes, potentially leading to changes in V5-Probe function. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662 is an AMP-activated protein kinase (AMPK) activator that indirectly modulates V5-Probe activity. By activating AMPK, A769662 can influence cellular energy homeostasis and downstream signaling pathways, potentially impacting V5-Probe function indirectly. | ||||||