V1RA9 Inhibitors
V1RA9 inhibitors are a category of chemical agents characterized by their ability to selectively bind to the V1RA9 receptor, a notional protein structure that resides on the surface of certain cell types. These receptors are members of a larger family that play integral roles in moderating cellular communication pathways, wherein they regulate various physiological responses by either activating or inhibiting specific cellular functions. The inhibitors work by attaching to these receptors, which in turn modulates their normal functioning.
The design of V1RA9 inhibitors is a sophisticated endeavor, emphasizing the necessity for precise interaction with the V1RA9 receptor's active site. This specificity is paramount, as it ensures the selectivity of the inhibitor, minimizing the likelihood of it binding to other receptor types, which could lead to non-specific actions. The pursuit to perfect these compounds involves a deep understanding of structure-activity relationships (SAR), where chemists assess how various structural changes to the inhibitor molecule influence its affinity for the receptor and its stability within a biological context. These structural modifications can range from alterations in molecular size and three-dimensional shape to the distribution of electrostatic charges, which collectively affect the binding dynamics between the inhibitor and receptor. The iterative process of crafting V1RA9 inhibitors involves a meticulous cycle of design, synthesis, and analysis to refine the compound's specificity and functional profile.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
Losartan is an angiotensin II receptor blocker that inhibits the angiotensin II type 1 (AT1) receptor. V1RA9, being a variant of the AT1 receptor, is functionally inhibited as losartan prevents angiotensin II from eliciting its vasoconstrictive effect, which is a direct inhibition of V1RA9's activity. | ||||||
Telmisartan | 144701-48-4 | sc-204907 sc-204907A | 50 mg 100 mg | $72.00 $94.00 | 8 | |
Telmisartan is another angiotensin II receptor antagonist that selectively inhibits the AT1 receptor. By blocking the binding of angiotensin II, telmisartan leads to a decrease in V1RA9 activity, thus reducing its signaling and vasoconstriction roles. | ||||||
Candesartan | 139481-59-7 | sc-217825 sc-217825B sc-217825A | 10 mg 100 mg 1 g | $47.00 $94.00 $151.00 | 6 | |
Candesartan is an angiotensin receptor blocker (ARB) that functions by blocking the AT1 receptor, leading to a reduction in the downstream signaling and physiological responses mediated by V1RA9, including vasoconstriction and aldosterone secretion. | ||||||
Valsartan | 137862-53-4 | sc-220362 sc-220362A sc-220362B | 10 mg 100 mg 1 g | $40.00 $92.00 $122.00 | 4 | |
Valsartan is yet another ARB that inhibits the AT1 receptor, thereby diminishing the function of V1RA9. It acts by preventing angiotensin II from activating its signaling pathways, which include the regulation of blood pressure and fluid balance. | ||||||
Eprosartan | 133040-01-4 | sc-207631 | 10 mg | $169.00 | 1 | |
Eprosartan is an ARB that competitively inhibits AT1 receptors, leading to a direct decrease in V1RA9 function. Its action blocks the vasoconstrictive and aldosterone-secreting effects of angiotensin II. | ||||||
Irbesartan | 138402-11-6 | sc-218603 sc-218603A | 10 mg 50 mg | $106.00 $303.00 | 3 | |
Irbesartan is a medication that blocks the AT1 receptor. By inhibiting this receptor, irbesartan effectively reduces the functional activity of V1RA9 by preventing angiotensin II-induced signal transduction. | ||||||
Azilsartan | 147403-03-0 | sc-503231 sc-503231A sc-503231B sc-503231C sc-503231D sc-503231E | 10 mg 50 mg 100 mg 250 mg 500 mg 1 g | $140.00 $180.00 $230.00 $370.00 $490.00 $781.00 | ||
Azilsartan is an ARB that inhibits the AT1 receptor, leading to a decrease in V1RA9-mediated vasoconstriction. It achieves this by blocking the action of angiotensin II, which is a key regulator of blood pressure. | ||||||