URO-10 Inhibitors
URO-10 inhibitors are a set of chemical compounds that can potentially decrease the functional activity of URO-10 through specific signaling pathways or biological processes that it is directly involved in. URO-10, a uroporphyrinogen decarboxylase, plays a critical role in the heme biosynthesis pathway, particularly in the conversion of uroporphyrinogen III to coproporphyrinogen III. The inhibitors target various components of this pathway, and their effects can indirectly lead to the functional inhibition of URO-10.
Among the URO-10 inhibitors, 5-Aminolevulinic Acid, Succinylacetone, Disulfiram, and Lead (II) Acetate disrupt the balance of intermediates in the heme biosynthesis pathway, influencing the availability of substrates for URO-10 and leading to its functional inhibition. Hydroxycobalamin indirectly influences this pathway by affecting the pool of succinyl-CoA,a substrate for heme biosynthesis. Griseofulvin inhibits the polymerization of microtubules, which can disrupt the localization and function of enzymes in the heme biosynthesis pathway, including URO-10.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxocobalamin Acetate | 22465-48-1 | sc-207740 | 250 mg | $330.00 | ||
Hydroxycobalamin acts as a cofactor for methylmalonyl-CoA mutase, which can indirectly influence the heme biosynthesis pathway by affecting the pool of succinyl-CoA, a substrate for heme biosynthesis, and potentially inhibit URO-10. | ||||||
Succinylacetone | 51568-18-4 | sc-212963 sc-212963B | 10 mg 100 mg | $336.00 $418.00 | ||
Succinylacetone is a potent inhibitor of aminolevulinic acid dehydratase, an enzyme upstream of URO-10 in the heme biosynthesis pathway. Its inhibition can affect the availability of substrates for URO-10, leading to its functional inhibition. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit aldehyde dehydrogenase, which may lead to accumulation of 5-aminolevulinic acid, a substrate for the heme biosynthesis pathway. This could potentially disrupt the balance of the pathway and inhibit URO-10. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin can inhibit the polymerization of microtubules, which may disrupt the localization and function of enzymes in the heme biosynthesis pathway, including URO-10. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $83.00 | ||
Lead (II) Acetate can inhibit aminolevulinic acid dehydratase, an enzyme upstream of URO-10 in the heme biosynthesis pathway, which can disrupt the balance of the pathway and inhibit URO-10. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Protoporphyrin is a competitive inhibitor of ferrochelatase. Its presence can disrupt the balance of intermediates in the heme biosynthesis pathway, potentially leading to functional inhibition of URO-10. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1039.00 $2866.00 $4306.00 $8170.00 | 19 | |
Desferrioxamine is an iron-chelating agent that can deplete the cellular iron pool. Iron is a necessary cofactor for enzymes in the heme biosynthesis pathway, so its depletion can lead to functional inhibition of URO-10. | ||||||
Levamisole Hydrochloride | 16595-80-5 | sc-205730 sc-205730A | 5 g 10 g | $42.00 $67.00 | 18 | |
Levamisole inhibits the enzymatic reduction of methemoglobin to hemoglobin, which can disrupt heme metabolism and potentially lead to inhibition of URO-10. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol inhibits bacterial protein synthesis and has been reported to interfere with mammalian mitochondrial protein synthesis, which could potentially disrupt the heme biosynthesis pathway and inhibit URO-10. | ||||||