UPase Inhibitors
UPase Inhibitors is a category of chemical compounds designed to target and modulate the activity of enzymes known as uridine phosphorylases (UPases). These enzymes play a vital role in nucleotide metabolism, specifically in the breakdown of uridine and deoxyuridine into uracil and ribose-1-phosphate. UPases are critical for maintaining the balance of nucleotide pools within cells, and their dysregulation can impact various cellular processes, including DNA and RNA synthesis. Inhibitors of UPases are developed to interact with these enzymes, interfering with their enzymatic activity and the downstream metabolic pathways that depend on them.
Structurally, UPase Inhibitors are designed to engage specific regions or active sites on UPases, thereby disrupting their normal catalytic function. By inhibiting UPase activity, these compounds can influence the availability of uridine and deoxyuridine for nucleotide biosynthesis, impacting cellular proliferation, RNA and DNA synthesis, and other processes reliant on nucleotides. Research into UPase Inhibitors is instrumental in understanding the intricacies of nucleotide metabolism and its role in cellular physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil (5-FU) is a pyrimidine analog used in cancer therapy. It can be metabolized by uridine phosphorylase, but its incorporation into RNA/DNA or its metabolism can lead to cytotoxicity. | ||||||
Uridine | 58-96-8 | sc-296685 sc-296685A | 1 g 25 g | $61.00 $100.00 | 1 | |
Elevated levels of uridine can feedback inhibit uridine phosphorylase activity. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $49.00 $73.00 $270.00 $458.00 $1758.00 $114.00 | 16 | |
Thymidine can act as a competitive inhibitor for uridine phosphorylase. | ||||||
O2,2′-Cyclouridine | 3736-77-4 | sc-257938 | 1 g | $132.00 | ||
This compound is an inhibitor of uridine phosphorylase, impacting pyrimidine metabolism. | ||||||
2-Thiouridine | 20235-78-3 | sc-220766 sc-220766A sc-220766B | 50 mg 100 mg 250 mg | $260.00 $401.00 $671.00 | 1 | |
Another uridine analog that can act as an inhibitor for uridine phosphorylase. | ||||||
6-Azauridine | 54-25-1 | sc-221082B sc-221082 sc-221082C sc-221082A | 500 mg 1 g 2 g 5 g | $97.00 $159.00 $295.00 $679.00 | ||
Acts as an inhibitor of pyrimidine synthesis enzymes, and its metabolism can also impact uridine phosphorylase activity. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
While primarily known as an antiviral, ribavirin can also influence pyrimidine metabolism and potentially influence uridine phosphorylase activity. | ||||||
Tetrahydrouridine | 18771-50-1 | sc-204339 | 10 mg | $416.00 | 1 | |
This is a known inhibitor of cytidine deaminase but can also influence uridine levels and thereby potentially affect uridine phosphorylase. | ||||||