UPase Activators
UPP1 activators primarily include molecules that increase intracellular cAMP levels, thereby stimulating UPP1 activity. UPP1, or uridine phosphorylase 1, is an enzyme involved in the catabolism of uridine to uracil. The regulation of uridine levels in the cell involves cAMP-dependent pathways, and thus, the modulation of cAMP levels influences UPP1 activity. A major class of chemicals that activate UPP1 includes phosphodiesterase such as IBMX, Dipyridamole, Rolipram, Cilostazol, Milrinone, Sildenafil, Zardaverine, Papaverine, Trequinsin, and Etazolate. The elevated cAMP levels can stimulate UPP1 by activating cAMP-dependent pathways involved in uridine catabolism.
Another class of UPP1 activators includes molecules that directly increase cAMP levels. Forskolin is a potent activator of adenylyl cyclase, which catalyzes the conversion of ATP to cAMP. Elevated cAMP levels can stimulate UPP1 activity. Adenosine, an endogenous purine nucleoside, activates adenosinereceptors, leading to enhanced cAMP production. This increase in cAMP can stimulate UPP1, as it is involved in catabolic pathways that are regulated by cAMP. Overall, the activation of UPP1 is tightly linked to the regulation of cAMP levels within the cell. Chemicals that either inhibit the breakdown of cAMP or stimulate its production can effectively increase UPP1 activity. As UPP1 plays a key role in the catabolism of uridine to uracil, the modulation of UPP1 activity can impact cellular uridine levels and, as a result, influence various biochemical processes within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine is an endogenous purine nucleoside that activates adenosine receptors. The increase in adenosine receptor activity enhances cAMP production, which can activate UPP1 as it is involved in the catabolism of uridine to uracil. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase, leading to increased cAMP levels. Elevated cAMP can stimulate UPP1 activity, as cAMP-dependent pathways are involved in the regulation of uridine levels. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterase, preventing the breakdown of cAMP. Increased cAMP levels can stimulate UPP1 by activating cAMP-dependent pathways involved in uridine catabolism. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $31.00 $102.00 | 1 | |
Dipyridamole is a phosphodiesterase inhibitor that increases cAMP levels. The rise in cAMP stimulates UPP1 activity, as UPP1 is involved in catabolic pathways regulated by cAMP. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor, leading to elevated cAMP levels. Increased cAMP stimulates UPP1 activity, as UPP1 is part of cAMP-dependent pathways controlling uridine levels. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol is a phosphodiesterase-3 inhibitor that increases intracellular cAMP levels. The elevated cAMP can activate UPP1, which is involved in the catabolic pathways regulated by cAMP. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a phosphodiesterase-3 inhibitor that raises cAMP levels. The increased cAMP levels stimulate UPP1 activity, as UPP1 is part of the cAMP-dependent pathways regulating uridine levels. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a dual phosphodiesterase 3/4 inhibitor that raises cAMP levels. The increased cAMP can stimulate UPP1 activity, as UPP1 is part of the cAMP-dependent pathways controlling uridine levels. | ||||||
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Papaverine is a phosphodiesterase inhibitor that increases cAMP levels. The elevated cAMP levels stimulate UPP1 activity, as UPP1 is part of cAMP-dependent pathways regulating uridine levels. | ||||||
Etazolate Hydrochloride | 35838-58-5 | sc-201186 sc-201186A | 5 mg 25 mg | $61.00 $255.00 | 5 | |
Etazolate is a phosphodiesterase 4 inhibitor that elevates cAMP levels. The increased cAMP can stimulate UPP1 activity, as UPP1 is part of the cAMP-dependent pathways regulating uridine levels. | ||||||