UGT2B38 Inhibitors
Chemical inhibitors of UGT2B38 can effectively disrupt the normal function of the enzyme through various methods of inhibition, primarily through competitive binding at the enzyme's active site. Androsterone, a steroid metabolite, competes with the natural substrates of UGT2B38, occupying the catalytic site and preventing the glucuronidation of other compounds. Similarly, flavonoids such as chrysin, quercetin, baicalein, naringenin, and the parent compound flavone, engage the active site of UGT2B38, each exhibiting a competitive mode of inhibition. These natural compounds share a common trait in their ability to bind to the same site as the endogenous substrates, thereby inhibiting the enzyme's activity. Ellagic acid and curcumin, another pair of plant-based inhibitors, engage directly with UGT2B38 in a similar fashion, binding to the active site and disrupting the glucuronidation process.
Other compounds like resveratrol, genistein, and the furanocoumarin 6,7-dihydroxybergamottin also target UGT2B38 in a direct manner. Resveratrol and genistein, both found in various plant sources, inhibit the enzyme by occupying the active site, which is the same mechanism employed by the aforementioned flavonoids. Kojic acid, on the other hand, known for its chelating properties, can bind to the catalytic site of UGT2B38, potentially altering the enzyme's conformation or the availability of the active site, which results in inhibition of the enzyme's glucuronidation capacity. These diverse compounds, although different in structure, all share the ability to inhibit UGT2B38 through direct interaction, which highlights the enzyme's susceptibility to competitive inhibition by a variety of chemical entities.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin is a flavonoid that can inhibit UGT2B38 by binding to the enzyme's active site, which prevents the binding and subsequent glucuronidation of the enzyme's natural substrates, resulting in direct inhibition of its activity. | ||||||
Flavone | 525-82-6 | sc-206027 sc-206027A | 1 g 5 g | $23.00 $68.00 | ||
Flavone, the parent compound of many flavonoids, can inhibit UGT2B38 by direct interaction with the enzyme, leading to a decrease in glucuronidation activity for other substrates due to competitive inhibition at the active site. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a plant flavonol that can inhibit UGT2B38 by directly binding to the enzyme's active site. This binding inhibits the normal glucuronidation process by preventing other substrates from interacting with the enzyme. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein, a flavone derived from the Scutellaria root, inhibits UGT2B38 by competing with endogenous substrates for the active site of the enzyme, which reduces the overall glucuronidation capacity of the enzyme. | ||||||
Kojic acid | 501-30-4 | sc-255228 sc-255228A | 5 g 25 g | $94.00 $176.00 | 1 | |
Kojic acid, known for its chelating properties, can inhibit UGT2B38 by binding to the catalytic site, potentially altering the enzyme's conformation or active site availability, leading to direct inhibition of enzyme activity. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin, a flavanone found in grapefruits, can inhibit UGT2B38 by competitively binding to the active site, which directly prevents the glucuronidation of the enzyme's natural substrates. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid, a natural phenol antioxidant found in various fruits, can inhibit UGT2B38 by directly interacting with the enzyme and disrupting its normal activity, leading to a reduction in glucuronidation of substrates. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a constituent of turmeric, can inhibit UGT2B38 through direct binding to the enzyme's active site, which inhibits the glucuronidation process of the natural substrates of the enzyme. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a stilbenoid found in grapes, can inhibit UGT2B38 by directly binding to the enzyme's active site, preventing the normal glucuronidation of its substrates, thus directly inhibiting the enzyme's function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone derived from soybeans, can inhibit UGT2B38 by competitive inhibition, where it binds to the active site of the enzyme, reducing the glucuronidation of other substrates. | ||||||