UGT2B Inhibitors

The chemical class of UGT2B Inhibitors includes compounds that indirectly modulate the function of UGT2B by affecting glucuronidation and related metabolic pathways. These inhibitors do not directly target UGT2B but influence the enzymatic activity and cellular environment in which UGT2B operates.Compounds such as Probenecid, Ketoprofen, Indomethacin, Fluconazole, Sulfinpyrazone, Isoniazid, Chloramphenicol, Gemfibrozil, and Piperine are known to interact with or inhibit glucuronidation enzymes. These interactions can disrupt the normal function of UGT2B in drug metabolism and detoxification processes. For instance, Probenecid and Indomethacin are noted for their ability to interfere with the glucuronidation process, which is a key function of UGT2B.

Other inhibitors, including Atazanavir, Crizotinib, and Lovastatin, affect different aspects of metabolic pathways and enzyme activities. Atazanavir and Crizotinib, through their actions as a protease inhibitor and an ALK inhibitor respectively, can indirectly modulate UGT2B's activity by influencing the metabolic processing of compounds. Lovastatin, known for its role in inhibiting cholesterol synthesis, might also impact UGT2B indirectly through lipid metabolism pathways.