UCP4 Activators
The chemical class of UCP4 activators comprises a diverse range of compounds primarily influencing mitochondrial function and energy metabolism. These activators function indirectly by modulating cellular pathways that affect mitochondrial biogenesis, membrane potential, and energy balance, which in turn can influence UCP4 expression and activity. The primary mechanism of action for these compounds involves the regulation of signaling pathways and transcription factors that govern mitochondrial dynamics and function.
Compounds such as resveratrol, metformin, and alpha-lipoic acid activate pathways that lead to enhanced mitochondrial biogenesis and efficiency. The increase in mitochondrial numbers and function necessitates a corresponding regulation of mitochondrial membrane potential, a process in which UCP4 is critically involved. As a response to these changes in mitochondrial dynamics, there could be an upregulation of UCP4 expression to maintain energy homeostasis and efficient cellular metabolism. Other compounds in this class, including berberine, curcumin, and naringenin, modulate various signaling pathways that influence mitochondrial health and energy metabolism. These changes in the cellular metabolic environment can lead to an adaptive increase in UCP4 expression, as UCP4 plays a pivotal role in uncoupling mitochondrial respiration, thereby regulating energy expenditure and protecting cells from oxidative stress.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol found in grapes, activates SIRT1, which influences mitochondrial biogenesis. Enhanced mitochondrial biogenesis could indirectly increase UCP4 expression as part of the adaptive response to increased mitochondrial numbers. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin activates AMPK, which promotes mitochondrial biogenesis and efficiency. Increased mitochondrial biogenesis can lead to a compensatory rise in UCP4 expression, as UCP4 plays a role in regulating mitochondrial membrane potential. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-Lipoic Acid influences mitochondrial biogenesis and may indirectly affect UCP4 expression by increasing the demand for mitochondrial uncoupling to maintain energy balance. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine activates AMPK, leading to enhanced mitochondrial function and possibly an increase in UCP4 expression to manage the mitochondrial membrane potential and energy expenditure. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates various signaling pathways and can influence mitochondrial function. This may indirectly lead to an increase in UCP4 expression, aiding in the regulation of mitochondrial membrane potential and cellular energy homeostasis. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin, found in citrus fruits, has been shown to affect mitochondrial function. Its impact on mitochondrial biogenesis and function could lead to an indirect increase in UCP4 expression as a response to altered mitochondrial dynamics. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin, the active component in chili peppers, can influence energy metabolism. While its direct effect on UCP4 is not established, its role in metabolic processes suggests it may indirectly affect UCP4 expression through changes in energy balance and mitochondrial function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a catechin in green tea, influences energy metabolism and mitochondrial function. This may indirectly lead to changes in UCP4 expression as part of the cellular response to altered mitochondrial dynamics. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is involved in the mitochondrial electron transport chain. By influencing mitochondrial efficiency, it may indirectly affect UCP4 expression to regulate membrane potential and cellular energy metabolism. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, activates Nrf2, which regulates cellular antioxidant response. Its role in mitochondrial function could indirectly lead to changes in UCP4 expression, as part of the adaptive cellular response to altered redox states. | ||||||