UBXD4 Activators
UBXD4 activators belong to a class of chemical compounds that specifically target and modulate the activity of the UBXD4 protein. UBXD4 is a protein involved in the regulation of endoplasmic reticulum-associated degradation (ERAD), a process responsible for eliminating misfolded or damaged proteins from the endoplasmic reticulum (ER). UBXD4 acts as an adaptor protein, facilitating the interaction between the ER-resident E3 ubiquitin ligase and the protein substrate, marking the substrate for degradation by the proteasome. By activating UBXD4, these compounds may enhance the efficiency of ERAD, leading to increased degradation of misfolded proteins and potentially improving cellular protein quality control mechanisms.
The mechanism by which UBXD4 activators exert their effects is not yet fully understood, but it is believed that they may enhance the binding of UBXD4 to its substrate proteins, promote the assembly of the ERAD complex, or stabilize the interaction between UBXD4 and the proteasome. By enhancing UBXD4 activity, these compounds may help cells cope with increased levels of misfolded or damaged proteins, which can occur under conditions of cellular stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
A specific inhibitor of the proteasomal degradation pathway, potentially augmenting the requirement for UBXD4 in handling ubiquitinated proteins. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can enhance the need for UBXD4's role in managing proteins destined for degradation. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
A selective proteasome inhibitor, potentially escalating the need for UBXD4 activity to address the build-up of polyubiquitinated proteins. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Induces endoplasmic reticulum stress, potentially upregulating UBXD4 as part of the unfolded protein response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Another inducer of endoplasmic reticulum stress, which may similarly require UBXD4 activity for dealing with misfolded proteins. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
An autophagy inhibitor that may lead to an accumulation of protein aggregates, possibly increasing the functional demand on UBXD4. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Induces premature chain termination during protein synthesis, leading to misfolded proteins that may require UBXD4 for processing. | ||||||