U1 snRNP 70 Activators
U1 snRNP 70 Activators encompass a diverse group of compounds, each uniquely influencing cellular and molecular pathways that indirectly modulate the function of U1 snRNP 70. These activators do not interact with U1 snRNP 70 directly but instead exert their effects through a cascade of intracellular signals and changes in the biochemical environment that ultimately impact the activity of U1 snRNP 70. Most of these compounds function by either activating or inhibiting key enzymes and pathways that are crucial for cellular signaling and gene expression. For instance, kinase activators or inhibitors like PMA and staurosporine alter the phosphorylation state of proteins, which is a critical regulatory mechanism in cellular processes, including RNA splicing and processing in which U1 snRNP 70 is involved. The phosphorylation or dephosphorylation of components of the spliceosome, the complex responsible for RNA splicing, can lead to changes in its assembly and function, thereby indirectly affecting U1 snRNP 70.
On the other hand, compounds like sodium butyrate and 5-azacytidine modulate gene expression at the epigenetic level. By altering histone acetylation or DNA methylation patterns, these chemicals can change the expression of genes that encode proteins involved in RNA processing, thereby indirectly influencing the activity of U1 snRNP 70. Similarly, resveratrol and curcumin, known for their roles in modulating cellular stress responses and metabolism, can lead to an altered cellular environment that indirectly affects U1 snRNP 70 function, particularly under conditions of cellular stress or altered metabolic states. Overall, the chemical class of "U1 snRNP 70 Activators" is defined not by a direct interaction with U1 snRNP 70, but rather by their ability to influence the broader cellular and molecular context within which U1 snRNP 70 operates. This indirect modulation is achieved through a diverse range of mechanisms, including changes in kinase and phosphatase activity, alterations in chromatin structure and gene expression, and modulation of cellular signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analog known to activate protein kinase C (PKC). PKC, in turn, plays a role in modulating spliceosome activity, which could indirectly activate U1 snRNP 70 as part of the spliceosomal complex. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels and thereby activating PKA. PKA can phosphorylate various proteins involved in RNA processing, potentially activating U1 snRNP 70 function indirectly. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
As a potent inhibitor of protein phosphatases PP1 and PP2A, okadaic acid indirectly influences phosphorylation states of numerous proteins, possibly activating U1 snRNP 70 by altering the phosphorylation-dependent spliceosome dynamics. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a polyphenol in green tea, has been shown to affect multiple signaling pathways, including those involving kinases and phosphatases, which could indirectly activate U1 snRNP 70 function through changes in spliceosome regulation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor, staurosporine non-selectively inhibits a wide range of protein kinases. This broad activity could indirectly activate U1 snRNP 70 through alterations in cellular phosphorylation patterns and subsequent spliceosome assembly or function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin affects various cellular processes, including modulation of transcription factors and enzymes involved in signal transduction. These effects could indirectly activate U1 snRNP 70 activity by altering the cellular environment and regulatory mechanisms of RNA splicing. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences glycogen synthase kinase 3 (GSK-3) activity. GSK-3 has numerous downstream effects, potentially including modulation of factors that interact with or regulate U1 snRNP 70. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
This histone deacetylase inhibitor affects chromatin structure and gene expression, potentially activating U1 snRNP 70 by altering the transcriptional landscape and availability of RNA processing components. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Known to disrupt Golgi apparatus function, brefeldin A can influence intracellular signaling and trafficking. These disruptions might indirectly activate U1 snRNP 70 function, particularly in relation to RNA transport and processing. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-azacytidine alters the epigenetic state of cells, potentially activating U1 snRNP 70 by changing the transcriptional profile and splicing patterns of RNA. | ||||||