TTLL6 Inhibitors
TTLL6 inhibitors belong to a class of compounds designed to specifically target and impede the activity of the enzyme tubulin tyrosine ligase-like 6 (TTLL6). TTLL6 is a member of the tubulin tyrosine ligase (TTLL) family, enzymes crucial for post-translational modification of alpha-tubulin in the assembly and maintenance of microtubules within cells. Microtubules are dynamic cytoskeletal structures that play pivotal roles in cellular processes such as intracellular transport, cell division, and maintenance of cell shape. TTLL6, in particular, is involved in the addition of tyrosine to the C-terminal of alpha-tubulin, a process known as tubulin tyrosination. This modification is essential for regulating microtubule dynamics and stability, influencing their interactions with molecular motors and associated proteins.
TTLL6 inhibitors represents a significant stride in the realm of chemical biology, offering researchers a tool to dissect the intricate mechanisms governing microtubule dynamics within the cellular milieu. By selectively inhibiting TTLL6, these compounds interfere with the tubulin tyrosination process, potentially leading to aberrant microtubule dynamics and cellular consequences. Understanding the impact of TTLL6 inhibition on cellular functions provides valuable insights into the broader regulatory network of microtubule-related processes and opens avenues for further investigations into the physiological and pathological roles of tubulin tyrosination
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubule polymerization by binding to β-tubulin, which can indirectly affect the function of TTLL6. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Binds to tubulin, preventing its polymerization into microtubules, thereby indirectly impacting TTLL6 activity. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Inhibits microtubule assembly by binding to tubulin, which could affect the substrate availability for TTLL6. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Inhibits the polymerization of tubulin, indirectly affecting TTLL6 by changing the microtubule structure it acts upon. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Inhibits microtubule growth, potentially altering polyglutamylation patterns regulated by TTLL6. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Disrupts microtubule function by interfering with microtubule assembly, which can affect TTLL6 indirectly. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $45.00 $79.00 | ||
Binds to tubulin at the colchicine site and inhibits its polymerization, thus could influence TTLL6 activity. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $45.00 $87.00 | 2 | |
Disrupts microtubule formation by binding to β-tubulin, potentially influencing TTLL6 activity. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
Inhibits microtubule polymerization, potentially affecting the activity of TTLL6. | ||||||