TSPAN2 Activators
TSPAN2 activators encompass a class of chemicals that affect various biochemical and cellular pathways leading to an indirect upregulation or enhanced functionality of Tetraspanin-2. These compounds modulate cellular environments, thereby altering the behavior of TSPAN2 within its native context-cell membranes. For instance, compounds like EGCG and curcumin are known for their broad modulatory effects on cell signaling and membrane dynamics. Their influence extends to the functionality of membrane proteins, including tetraspanins, by altering the properties of the lipid bilayer or by triggering specific signaling cascades that could lead to increased expression or stabilization of TSPAN2.
Cholesterol and other membrane-intercalating compounds such as simvastatin and methyl-β-cyclodextrin impact the physical characteristics of the cellular membrane, which is critical for the organization of tetraspanin-enriched microdomains (TERMs), and therefore, can affect TSPAN2 activity. Signaling molecules like S1P, LPA, and cAMP, as well as modulators of protein kinases such as PMA, do not interact directly with TSPAN2 but can initiate a sequence of intracellular events that promote changes in tetraspanin functions. These effects may range from altered cell adhesion and motility to changes in intracellular signaling.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A catechin found in green tea that may enhance the expression of TSPAN2 by modulating lipid rafts and associated signaling pathways. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Essential component of membrane microdomains that can influence the organization and function of tetraspanins including TSPAN2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A diacylglycerol analog that activates protein kinase C (PKC) and can modulate the distribution of tetraspanins in the plasma membrane. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
A bioactive lipid that engages signaling pathways potentially affecting tetraspanin function through alterations in cell adhesion and migration. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
An HMG-CoA reductase inhibitor that alters cholesterol biosynthesis and can indirectly affect the functionality of tetraspanin-enriched microdomains. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
A secondary messenger that can alter cellular signaling pathways and potentially impact the expression and function of TSPAN2. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
A glycerophospholipid that can activate G protein-coupled receptors and influence tetraspanin function in cell adhesion and motility. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A bioactive compound from turmeric that modulates various signaling pathways and might affect tetraspanin protein levels and function. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $42.00 $83.00 $155.00 | 7 | |
Donors can regulate signaling pathways by modulating cGMP levels, thereby affecting tetraspanin functions. | ||||||
2-Hydroxypropyl-β-cyclodextrin | 128446-35-5 | sc-203461 sc-203461B sc-203461C sc-203461A | 1 g 100 g 500 g 5 g | $52.00 $620.00 $1950.00 $130.00 | 8 | |
A cholesterol-depleting agent that disrupts lipid rafts, potentially affecting the localization and function of tetraspanins. | ||||||