TRMT5 Inhibitors
TRMT5 inhibitors play a crucial role in modulating tRNA methylation by influencing the availability and function of essential substrates and cofactors necessary for its activity. The inhibition of TRMT5 can be achieved through the depletion of S-Adenosylmethionine (SAM), which is a primary methyl donor in the methylation process catalyzed by TRMT5. Compounds that affect the synthesis or availability of SAM indirectly inhibit TRMT5 by limiting its essential methyl donor substrate. For example, molecules that can act as competitive inhibitors or that deplete SAM levels, such as analogues of methionine or products of methylation reactions, can reduce the methyltransferase activity of TRMT5. Additionally, compounds that inhibit enzymes responsible for SAM synthesis or that increase concentrations of SAM competitors can also lead to a decrease in TRMT5 function. Furthermore, inhibition of adenosine uptake can limit the cellular pool of adenosine, a component of SAM, thus affecting TRMT5 activity.
Other chemicals may inhibit TRMT5 by altering the methylation equilibrium within the cell. Certain analogs of cytidine, when incorporated into RNA, can disrupt the normal methylation processes, and this disruption could extend to the methylation patterns that TRMT5 is responsible for maintaining. Similarly, agents that induce demethylation of nucleic acids might also influence the methylation activity of TRMT5. Inhibition of glutamine-utilizing enzymes affects the synthesis of various methylation-related metabolites, thereby indirectly influencing TRMT5's enzymatic activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
Serves as a methyl donor in methylation reactions catalyzed by enzymes such as TRMT5, thus its depletion would result in reduced methylation activity including that of TRMT5. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
Elevated homocysteine levels can competitively inhibit methionine synthesis, indirectly reducing the availability of S-Adenosylmethionine, which is critical for TRMT5 function. | ||||||
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $120.00 | 1 | |
This molecule competes with S-Adenosylmethionine for binding sites, potentially inhibiting methyltransferase enzymes like TRMT5 by substrate competition. | ||||||
1-Aminocyclopentanecarboxylic acid | 52-52-8 | sc-202392 | 1 g | $23.00 | ||
Acts as an inhibitor of methionine adenosyltransferase, the enzyme responsible for the synthesis of S-Adenosylmethionine, thereby indirectly inhibiting TRMT5 activity due to lack of substrate. | ||||||
Azaserine | 115-02-6 | sc-29063 sc-29063A | 50 mg 250 mg | $306.00 $906.00 | 15 | |
Inhibits glutamine-utilizing enzymes, which could lead to decreased levels of S-Adenosylmethionine, indirectly reducing the methyltransferase activity of TRMT5. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Impairs the synthesis of methionine and consequently S-Adenosylmethionine, indirectly inhibiting TRMT5 by substrate limitation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A cytidine analog that, when incorporated into RNA, can disrupt methylation processes and potentially inhibit TRMT5 activity indirectly by altering methylation patterns. | ||||||
1-Hydrazinophthalazine Hydrochloride | 304-20-1 | sc-206167 | 10 g | $280.00 | ||
Known to demethylate DNA indirectly, which may extend to RNA demethylation, thereby potentially inhibiting the RNA methylation activity of TRMT5. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
A vitamin B3 analog that has been shown to inhibit certain methylation reactions, could indirectly reduce TRMT5 activity by altering the cellular methylation balance. | ||||||