TRAP240 Activators
TRAP240 activators encompass a spectrum of chemical compounds that enhance the functional activity of TRAP240 either directly or indirectly. Some activators function via kinase inhibition, such as Staurosporine, U0126, PD98059, LY294002, Wortmannin, and Triciribine. These chemicals can alter the phosphorylation state of transcription factors, thereby indirectly enhancing TRAP240 activity, given its role in transcriptional regulation.
Other activators, such as Forskolin, impact adenylate cyclase, leading to enhanced cAMP levels and subsequent stimulation of PKA. This PKA surge can influence the phosphorylation state of transcription factors, indirectly activating TRAP240. Compounds like Resveratrol, Niacin, and Quercetin activate SIRT1, which can modify the acetylation state of transcription factors, indirectly enhancing TRAP240 function. Lastly, Metformin, as an AMPK activator, may also enhance TRAP240 function by impacting cellular energy status and influencing the phosphorylation state of transcription factors.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent, cell-permeable protein kinase C (PKC) inhibitor that can suppress PKC-mediated phosphorylation. TRAP240 has been associated with transcriptional regulation, and PKC is known to phosphorylate transcription factors, potentially enhancing TRAP240's function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An activator of adenylate cyclase, Forskolin enhances cAMP levels, stimulating PKA. The increased PKA can phosphorylate certain transcription factors, indirectly activating TRAP240. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Another MEK inhibitor, PD 98059 can similarly lead to less suppression of the ERK pathway, altering the phosphorylation state of transcription factors and potentially enhancing TRAP240 function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
As a SIRT1 activator, Resveratrol can alter the acetylation state of transcription factors, which may enhance the function of TRAP240. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Acting as a precursor of NAD+, a co-factor for SIRT1, Niacin can enhance SIRT1 activity, potentially enhancing the acetylation state of transcription factors and indirectly activating TRAP240. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Another SIRT1 activator, Quercetin can enhance the function of TRAP240 by modifying the acetylation state of transcription factors. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a PI3K inhibitor, LY294002 can lead to less suppression of the AKT pathway, altering the phosphorylation state of transcription factors and potentially enhancing TRAP240 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor, Wortmannin can also lead to less suppression of the AKT pathway, potentially enhancing the functional activity of TRAP240 by altering the phosphorylation state of transcription factors. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
An AKT inhibitor, Triciribine can reduce AKT-mediated suppression of the PI3K pathway, leading to altered phosphorylation state of transcription factors and potentially enhancing TRAP240 function. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
An AMPK activator, Metformin can lead to phosphorylation of transcription factors, potentially enhancing TRAP240 function by influencing cellular energy status. | ||||||