Date published: 2025-10-26

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TMX3 Activators

TMX3 Activators are a curated collection of chemical compounds that indirectly enhance the activity of TMX3 through specific intracellular pathways. For instance, Forskolin, Ionomycin, 8-Br-cAMP, and A23187 elevate intracellular cAMP and calcium levels, respectively, which activate PKA and calmodulin-dependent pathways. These pathways, in turn, promote phosphorylation events and calcium signaling that are critical for the endoplasmic reticulum (ER) functions where TMX3 is known to operate, particularly in protein folding and stress response mechanisms. PMA serves to modulate PKC activity, further influencing the ER stress pathways and potentially enhancing the chaperone activity of TMX3.

Chemical chaperones like 4-Phenylbutyrate alleviate ER stress by assisting in protein folding, suggesting an indirect mechanism to enhance the functional capacity of TMX3 by reducing the burden of unfolded proteins. Furthermore, Salubrinal and Guanabenz, which inhibit the dephosphorylation of eIF2α, provide a biochemical milieu that supports the UPR, a cellular process where TMX3's role is pivotal. TMX3 activators can bolster the protein's capacity to manage ER stress and maintain protein quality control, ensuring cellular proteostasis without directly upregulating its expression or activity.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin activates adenylyl cyclase, raising intracellular cAMP levels, which in turn activates PKA. PKA phosphorylates multiple targets that could interact with TMX3 to enhance its protein folding and quality control functions within the endoplasmic reticulum.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Ionomycin acts as a calcium ionophore, increasing intracellular calcium concentration. Elevated calcium levels can activate calmodulin and other calcium-binding proteins that may regulate TMX3's activity in maintaining calcium homeostasis and ER stress response.

8-Bromo-cAMP

76939-46-3sc-201564
sc-201564A
10 mg
50 mg
$97.00
$224.00
30
(1)

8-Br-cAMP is a cell-permeable cAMP analogue that directly activates cAMP-dependent PKA. PKA then enhances the phosphorylation status of proteins that could modulate the functional activity of TMX3 in the ER-associated degradation (ERAD) pathway.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates protein kinase C (PKC), which can phosphorylate substrates that may alter TMX3's role in protein folding and stress response pathways in the endoplasmic reticulum.

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$54.00
$128.00
$199.00
$311.00
23
(1)

A23187 is an ionophore that selectively increases intracellular calcium levels, potentially enhancing TMX3's role in calcium homeostasis and the ER stress response.

Sodium phenylbutyrate

1716-12-7sc-200652
sc-200652A
sc-200652B
sc-200652C
sc-200652D
1 g
10 g
100 g
1 kg
10 kg
$75.00
$163.00
$622.00
$4906.00
$32140.00
43
(1)

4-Phenylbutyrate is a chemical chaperone that relieves ER stress, which may indirectly enhance TMX3's function in protein folding and ER stress response by reducing the protein load within the ER.

Salubrinal

405060-95-9sc-202332
sc-202332A
1 mg
5 mg
$33.00
$102.00
87
(2)

Salubrinal selectively inhibits phosphatases that dephosphorylate eIF2α, leading to increased resistance to ER stress and potentially enhancing the role of TMX3 in the UPR.

Guanabenz acetate

23256-50-0sc-203590
sc-203590A
sc-203590B
sc-203590C
sc-203590D
100 mg
500 mg
1 g
10 g
25 g
$100.00
$459.00
$816.00
$4080.00
$7140.00
2
(2)

Guanabenz is reported to alleviate ER stress by inhibiting the dephosphorylation of eIF2α, which could indirectly lead to the activation of TMX3 by enhancing the UPR pathway.