TMEM231 Inhibitors

Chemicals classified as TMEM231 Inhibitors are compounds that can indirectly affect the functional pathways of the TMEM231 protein. Since TMEM231 is implicated in the structure and function of primary cilia and the Shh signaling pathway, compounds that disrupt these functions can serve as indirect inhibitors. Cyclopamine, vismodegib, GANT61, jervine, SANT1, SANT2, and itraconazole are examples of molecules that target the Shh pathway at different points; cyclopamine and jervine by directly interfering with components like Smoothened or the Gli transcription factors, while vismodegib, SANT1, SANT2, and itraconazole act as antagonists to Smoothened, thereby hindering the pathway's activation and possibly affecting the functional contributions of TMEM231.

On the other hand, compounds like forskolin, U18666A, mebendazole, ciliobrevin A, and ciliobrevin D affect the ciliary structure and function. Forskolin, by increasing cAMP levels, can modulate ciliary beat frequency and function, while U18666A can alter the composition of the ciliary membrane. Mebendazole compromises microtubule stability, thus potentially affecting ciliogenesis and ciliary maintenance where TMEM231 is involved. Ciliobrevin A and D inhibit ciliary trafficking and hence can influence TMEM231's role in ciliary assembly and function.